INT107433

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Context Info
Confidence 0.56
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.44
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
spinal cord 2
dorsal horn 1
Casp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 12 100.00 Very High Very High Very High
metalloproteinase 6 100.00 Very High Very High Very High
Inflammation 21 99.88 Very High Very High Very High
Spinal cord 12 99.84 Very High Very High Very High
Osteoarthritis 2 97.96 Very High Very High Very High
antagonist 3 97.32 Very High Very High Very High
Dorsal horn 9 95.88 Very High Very High Very High
anesthesia 1 90.84 High High
Hyperalgesia 3 90.44 High High
Pain 2 89.84 High High
Disease Link Frequency Relevance Heat
Myelitis 9 99.84 Very High Very High Very High
Apoptosis 3 99.80 Very High Very High Very High
Nociception 9 98.52 Very High Very High Very High
Osteoarthritis 3 97.96 Very High Very High Very High
INFLAMMATION 3 96.76 Very High Very High Very High
Syndrome 2 93.68 High High
Nervous System Injury 3 91.40 High High
Hyperalgesia 3 90.44 High High
Pain 1 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest a critical role for the cytokine IL-1beta and caspase 1 rapidly released by activated microglia in enhancing nociceptive transmission in spinal cord inflammation.
Localization (released) of caspase 1 in spinal cord associated with nociception, inflammation, spinal cord and cytokine
1) Confidence 0.56 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16942597 Disease Relevance 0.66 Pain Relevance 0.62
LPS superfusion also induced rapid secretion of active caspase 1 and apoptosis-associated speck-like protein containing a caspase recruitment domain from the isolated dorsal horn.
Localization (secretion) of caspase 1 in dorsal horn associated with dorsal horn and apoptosis
2) Confidence 0.56 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16942597 Disease Relevance 0.65 Pain Relevance 0.54
Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation.
Localization (co-release) of caspase 1 in spinal cord associated with inflammation and spinal cord
3) Confidence 0.52 Published 2006 Journal J. Neurochem. Section Title Doc Link 16942597 Disease Relevance 0.68 Pain Relevance 0.65
Halogenated anesthetics reduce interleukin-1beta-induced cytokine secretion by rat alveolar type II cells in primary culture.
Localization (secretion) of interleukin-1beta-induced associated with cytokine
4) Confidence 0.06 Published 2003 Journal Anesthesiology Section Title Doc Link 12502982 Disease Relevance 0 Pain Relevance 0.42
OBJECTIVE: The NALP3 inflammasome is a multiprotein complex that triggers caspase 1-mediated interleukin-1beta (IL-1beta) release.
Localization (release) of caspase 1
5) Confidence 0.05 Published 2010 Journal Arthritis Rheum. Section Abstract Doc Link 20506209 Disease Relevance 0.17 Pain Relevance 0
We tested the hypothesis that hyaluronan inhibited interleukin-1beta-induced matrix metalloproteinase activity secreted by explants of synovial tissue from patients with osteoarthritis and investigated the mechanism of the effect.
Localization (secreted) of interleukin-1beta-induced associated with metalloproteinase and osteoarthritis
6) Confidence 0.01 Published 2007 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 18090474 Disease Relevance 0.28 Pain Relevance 0.41

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