INT107457

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Context Info
Confidence 0.30
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 1.26
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Smn1) nucleolus (Smn1) RNA binding (Smn1)
nucleus (Smn1) cytoplasm (Smn1)
Anatomy Link Frequency
motor neuron 1
Smn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 2 99.86 Very High Very High Very High
ischemia 1 99.52 Very High Very High Very High
TRP channel 1 95.80 Very High Very High Very High
Calcitonin gene-related peptide 39 94.56 High High
cerebral cortex 2 92.00 High High
antagonist 41 89.04 High High
anesthesia 1 82.68 Quite High
cINOD 3 76.36 Quite High
agonist 22 68.72 Quite High
qutenza 14 59.52 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 99.86 Very High Very High Very High
Cv Unclassified Under Development 1 99.52 Very High Very High Very High
Brain Injury 6 97.16 Very High Very High Very High
Neurodegenerative Disease 1 96.72 Very High Very High Very High
Spinal Muscular Atrophy 1 95.68 Very High Very High Very High
Injury 1 94.44 High High
Disease 4 88.56 High High
Death 1 81.52 Quite High
Shock 1 58.64 Quite High
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The negative feedback may become operative during ischemia and inflammation which stimulate SMN activity.
Positive_regulation (stimulate) of SMN associated with inflammation and ischemia
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0.36 Pain Relevance 0.70
These include up-regulated transcription factors (SOCS-3, JAK-2, STAT-3, CREM, IRF-1, SMN, silencer factor-B, ANIA-3, ANIA-4, and HES-1) and signal transduction pathways (cpg21, Narp, and CRBP) and down-regulated transmitter release mechanisms (CITRON, synaptojanin II, ras-related rab3, neurexin-1beta, and SNAP25A and -B), kinases (IP-3-kinase, Pak1, Ca(2+)/CaM-dependent protein kinases), and ion channels (K(+) channels TWIK, RK5, X62839, and Na(+) channel I).
Positive_regulation (up-regulated) of SMN
2) Confidence 0.16 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12503083 Disease Relevance 0.63 Pain Relevance 0.22
Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism.
Positive_regulation (upregulates) of neuron protein in motor neuron
3) Confidence 0.00 Published 2004 Journal Chem. Biol. Section Title Doc Link 15555999 Disease Relevance 0.27 Pain Relevance 0.22

General Comments

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