INT107539

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Context Info
Confidence 0.66
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 13
Disease Relevance 8.32
Pain Relevance 12.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Csad) cellular_component (Csad)
Anatomy Link Frequency
brain 1
Csad (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 261 100.00 Very High Very High Very High
depression 30 100.00 Very High Very High Very High
Morphine 616 99.92 Very High Very High Very High
primary somatosensory cortex 392 99.84 Very High Very High Very High
antagonist 42 99.78 Very High Very High Very High
Glutamate 2 99.74 Very High Very High Very High
Anterior cingulate cortex 469 99.68 Very High Very High Very High
agonist 42 99.48 Very High Very High Very High
Gabapentin 8 98.92 Very High Very High Very High
Migraine 24 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 30 100.00 Very High Very High Very High
Targeted Disruption 666 99.24 Very High Very High Very High
Epilepsy 4 99.08 Very High Very High Very High
Headache 23 98.88 Very High Very High Very High
Nociception 210 98.76 Very High Very High Very High
Brain Injury 4 98.08 Very High Very High Very High
Migraine With Aura 3 75.00 Quite High
Injury 2 65.60 Quite High
Brain Disease 1 51.20 Quite High
Neurological Disease 1 37.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence for a causative link between enhanced glutamate release and CSD facilitation was obtained.
Gene_expression (facilitation) of CSD associated with glutamate and depression
1) Confidence 0.66 Published 2010 Journal J. Physiol. (Lond.) Section Abstract Doc Link 20194127 Disease Relevance 1.21 Pain Relevance 1.11
As Ca(v)2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca(v)2.1 through high-affinity binding to its alpha(2)delta subunit, on CSD susceptibility in anesthetized rats.
Gene_expression (modulate) of CSD associated with depression and gabapentin
2) Confidence 0.60 Published 2010 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 20588320 Disease Relevance 0.90 Pain Relevance 0.73
Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura.
Gene_expression (depression) of CSD in brain associated with epilepsy, depression, migraine and brain injury
3) Confidence 0.53 Published 2010 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 20588320 Disease Relevance 0.85 Pain Relevance 0.67
Longer treatment durations produced stronger CSD suppression.
Gene_expression (produced) of CSD
4) Confidence 0.51 Published 2006 Journal Ann. Neurol. Section Body Doc Link 16450381 Disease Relevance 0.15 Pain Relevance 0
The effect of morphine on evoked CSD profiles in the ACC
Gene_expression (profiles) of CSD associated with anterior cingulate cortex and morphine
5) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.49 Pain Relevance 0.69
Effect of GABAB agonist and antagonist on evoked CSD responses in the ACC
Gene_expression (responses) of CSD associated with antagonist, agonist and anterior cingulate cortex
6) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.49 Pain Relevance 1.65
Although there was a difference in the layer distribution of the sink and source currents, similar evoked CSD profiles in the ACC were observed in rats in our previous study [21].
Gene_expression (profiles) of CSD associated with anterior cingulate cortex
7) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.40 Pain Relevance 0.25
Typical examples of the effect of morphine on CSD profiles in S1 in both WT and KO mice are shown in Figure 4A.
Gene_expression (profiles) of CSD associated with targeted disruption, primary somatosensory cortex and morphine
8) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.56 Pain Relevance 0.93
The CSD profiles across the depth of cortical layers in WT (n = 18) and KO (n = 16) mice following laser stimulation are shown in Figure 3B.
Gene_expression (profiles) of CSD associated with targeted disruption
9) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.60 Pain Relevance 0.56
In the S1, morphine decreased the CSD profile evoked by electrical stimulation to 61.5 ± 9.9% of the control amplitude in WT mice (n = 8) and 29.7 ± 6.7% of the control amplitude in KO mice (n = 6).
Gene_expression (profile) of CSD associated with targeted disruption, primary somatosensory cortex and morphine
10) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.50 Pain Relevance 1.43
Acute nociceptive responses in the cortical regions indicated by alteration of CSD profiles did not differ in KO mice compared to WT mice, indicating that the enkephalin system is not directly involved in acute and phasic nociceptive transmission.
Gene_expression (profiles) of CSD associated with targeted disruption, nociception and enkephalin
11) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.91 Pain Relevance 1.27
The magnitude of the in vitro and in vivo resistance of 3 synthetic enkephalin analogs, [D-Ala2,Met5]-enkephalin (DAME), [D-Ala2,Met5]-enkephalinamide (DAME-NH2) and [D-Ala2,D-Met5]enkephalin (DADME), to 3 enkephalin-hydrolyzing enzymes, amastatin-sensitive aminopeptidase (AsA), phosphoramidon-sensitive endopeptidase-24.11 (PsE) and captopril-sensitive dipeptidyl carboxypeptidase I (CsD), was estimated by comparing the potency of enkephalins in the absence of the peptidase inhibitor (PI) with that in the presence of the PI.
Gene_expression (resistance) of CsD associated with enkephalin and potency
12) Confidence 0.14 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 12506418 Disease Relevance 0 Pain Relevance 1.78
CSD, BBB and MMP-9 elevations: animal experiments versus clinical phenomena in migraine.
Gene_expression (elevations) of CSD associated with migraine
13) Confidence 0.08 Published 2009 Journal Expert Rev Neurother Section Title Doc Link 19903020 Disease Relevance 1.25 Pain Relevance 1.06

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