INT107576

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2011
Negated 3
Speculated 7
Reported most in Body
Documents 114
Total Number 121
Disease Relevance 72.42
Pain Relevance 38.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Atf3) nucleus (Atf3) DNA binding (Atf3)
Anatomy Link Frequency
neurons 29
Schwann cells 18
nerve 8
DRG 8
macrophage 5
Atf3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 409 100.00 Very High Very High Very High
cytokine 99 100.00 Very High Very High Very High
Neuropeptide 88 100.00 Very High Very High Very High
sodium channel 17 100.00 Very High Very High Very High
Calcium channel 11 100.00 Very High Very High Very High
Calcitonin gene-related peptide 9 100.00 Very High Very High Very High
Spinal cord 976 99.88 Very High Very High Very High
Neuropathic pain 385 99.76 Very High Very High Very High
Sciatic nerve 1043 99.68 Very High Very High Very High
Arthritis 54 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 1847 100.00 Very High Very High Very High
Nervous System Injury 581 100.00 Very High Very High Very High
Ganglion Cysts 518 100.00 Very High Very High Very High
Stress 132 100.00 Very High Very High Very High
Toxicity 22 100.00 Very High Very High Very High
Neuropathic Pain 839 99.76 Very High Very High Very High
Targeted Disruption 24 99.68 Very High Very High Very High
Arthritis 64 99.60 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 763 99.24 Very High Very High Very High
Osteoarthritis 4 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, in our study, it appeared that the decreased availability of target-derived growth factors due to the degeneration of IENF following paclitaxel administration induced expression of ATF3.
Gene_expression (expression) of ATF3
1) Confidence 0.78 Published 2010 Journal Mol Pain Section Body Doc Link PMC2991291 Disease Relevance 0.49 Pain Relevance 0.08
Extracorporeal shockwaves induce the expression of ATF3 and GAP-43 in rat dorsal root ganglion neurons.
Gene_expression (expression) of ATF3 in dorsal root ganglion associated with ganglion cysts, nociceptor and root ganglion neuron
2) Confidence 0.78 Published 2006 Journal Auton Neurosci Section Title Doc Link 16716760 Disease Relevance 0.50 Pain Relevance 0.75
In order to investigate expression of ATF3, the sections were stained with anti-ATF3 antibody (see below).


Spec (investigate) Gene_expression (expression) of ATF3
3) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.12 Pain Relevance 0.27
Thus, nerve repair should be performed as soon as possible to utilise the expression of regeneration associated factors, such as ATF3, in both neurons and Schwann cells.
Gene_expression (expression) of ATF3 in Schwann cells
4) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.73 Pain Relevance 0
ATF3 expression in the sciatic nerve, spinal cord and the dorsal root ganglia (DRG)
Gene_expression (expression) of ATF3 in dorsal root ganglia associated with sciatic nerve and spinal cord
5) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.22 Pain Relevance 0.25
No data are available for a connection between the expression of ATF3 and the regeneration of motor fibers.
Gene_expression (expression) of ATF3
6) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0 Pain Relevance 0.08
ATF3 expression is long lasting in sensory, but not in motor, neurons if regeneration is prevented [16].
Gene_expression (expression) of ATF3 in neurons
7) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.09 Pain Relevance 0
Expression of ATF3 in Schwann cells has been seen rapidly after nerve injury [13,14,16,29], but was significantly decreased if repair was delayed for more than 30 days.
Gene_expression (Expression) of ATF3 in nerve associated with nervous system injury
8) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.48 Pain Relevance 0.13
The synthesis of NGFR/p75 in denervated Schwann cells has a similar time course as ATF3 expression with a peak at one month.
Gene_expression (expression) of ATF3 in Schwann cells
9) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.24 Pain Relevance 0
One may suggest from our and other studies that ATF3 expression in Schwann cells is important for the support of regeneration [14].
Gene_expression (expression) of ATF3 in Schwann cells
10) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0 Pain Relevance 0.03
In addition, reinnervation of target gives a more rapid decline of ATF3 expression [16].
Gene_expression (expression) of ATF3
11) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.06 Pain Relevance 0
ATF3 expression in Schwann cells decreased with time after denervation in the absence of regeneration [16,17].
Gene_expression (expression) of ATF3 in Schwann cells
12) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.06 Pain Relevance 0
The number of Schwann cells expressing ATF3 decreased with delayed nerve repair and did not increase after repair when compared with previous data [16].
Gene_expression (expressing) of ATF3 in Schwann cells
13) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.34 Pain Relevance 0
Interestingly, the number of ATF3 stained neurons and Schwann cells and length of axonal outgrowth correlated when all groups were examined, indicating that delayed nerve repair influences axonal outgrowth and ATF3 expression in neurons and Schwann cells.
Gene_expression (expression) of ATF3 in Schwann cells
14) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0 Pain Relevance 0
We found a correlation between the number of ATF3 expressing neurons and axonal outgrowth.
Gene_expression (expressing) of ATF3 in neurons
15) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0 Pain Relevance 0.08
Retransection of the axons at the time of delayed nerve repair, which is necessary for coaptation, may influence expression of ATF3, since the number of ATF3 expressing neurons was lower than that found when a transection was not repaired [16].
Gene_expression (expressing) of ATF3 in neurons
16) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.07 Pain Relevance 0
Retransection of the axons at the time of delayed nerve repair, which is necessary for coaptation, may influence expression of ATF3, since the number of ATF3 expressing neurons was lower than that found when a transection was not repaired [16].
Gene_expression (expression) of ATF3 in neurons
17) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.07 Pain Relevance 0
Interestingly, the decrease was faster if the nerve was repaired, as in the present study, compared to previous studies when regeneration was not permitted [16], signifying that expression of ATF3 in motor neurons is dependent on interaction between motor neurons and Schwann cells.
Gene_expression (expression) of ATF3 in Schwann cells
18) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0 Pain Relevance 0.08
ATF3 expression in Schwann cells and Schwann cell proliferation, influenced by Erk1/2 expression [8], occurs in the distal nerve segment within a few days of injury [13,14,16,29].
Gene_expression (expression) of ATF3 in Schwann cell associated with injury
19) Confidence 0.77 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.22 Pain Relevance 0
To define the population of cells injured by paclitaxel, we examined the expression of activating transcription factor-3 (ATF3), a marker of cell injury; to define the hypertrophy of satellite cells, we quantified the expression of the intermediate filament protein glial fibrillary acidic protein (GFAP); and to define the activation of macrophages, we examined the expression of the lysosomal protein CD68.
Spec (examined) Gene_expression (expression) of ATF3 in macrophages associated with hypertrophy and injury
20) Confidence 0.77 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16854522 Disease Relevance 0.79 Pain Relevance 0.13

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