INT10763

Context Info Confidence 0.80 First Reported 1983 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 157 Total Number 158 Disease Relevance 81.11 Pain Relevance 33.21

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2) cell-cell signaling (IL2)

Anatomy Link Frequency T cells 23 NK cells 8 lymphocytes 7 T-helper cell 6 monocytes 5 IL2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 1928 100.00 Inflammation 1432 100.00 headache 114 100.00 Opioid 46 100.00 intrathecal 5 99.98 spinal inflammation 70 99.84 opioid receptor 28 99.80 noradrenaline 6 99.76 Multiple sclerosis 118 99.72 Cluster headache 2 99.56

Disease Link Frequency Relevance Heat Cancer 1853 100.00 INFLAMMATION 1659 100.00 Necrosis 93 100.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 1208 99.84 Infection 437 99.84 Low Back Pain 88 99.84 Demyelinating Disease 104 99.72 Toxicity 98 99.68 Paralysis 10 99.60 Cluster Headache 2 99.56

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Mutation

Event

Anatomy

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Speculation

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Disease term

The increased IL-2 synthesis by PBMCs was not accompanied by a systemic (in vivo) release of IL-2 in response to any of the interventions.

Localization (release) of IL-2

1) Confidence 0.80 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0

Thus, an increase in the number of IL-2 secreting DCs in the PBMC preparations examined after the intervention, might explain the observed increase in IL-2 production in cultures derived from SMT-C and SMT-NC – treated subjects.

Localization (secreting) of IL-2

2) Confidence 0.80 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.16 Pain Relevance 0

The levels of IL-2 released spontaneously in cultures from the remaining subjects showed no significant alterations over the study period.

Localization (released) of IL-2

3) Confidence 0.80 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0

The results of the present study demonstrate clearly that manipulative intervention provided by spinal manipulation of the thoracic spine, results in a significant augmentation of IL-2 secretion in vitro induced by SPA.

Localization (secretion) of IL-2 in spine

4) Confidence 0.80 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0

Similarly, constitutive (spontaneous) in vitro secretion of IL-2 remained consistently comparable in all study groups.

Localization (secretion) of IL-2

5) Confidence 0.80 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0.03

In RR there is a sudden enhancement of already existing DTH to M. leprae and its antigens resulting in the release of excessive quantities of TNF alpha, INF gamma, and IL-2.

Localization (release) of IL-2

6) Confidence 0.78 Published 1996 Journal Indian J Lepr Section Abstract Doc Link 8727113 Disease Relevance 0.86 Pain Relevance 0.07

Interleukin-2 (IL-2) is a polypeptide secreted by antigen or mitogen-actuated T lymphocytes that functions as a growth factor for T cells.

Localization (secreted) of IL-2 in T cells

7) Confidence 0.78 Published 1991 Journal Headache Section Abstract Doc Link 1860789 Disease Relevance 0.62 Pain Relevance 0.62

Interleukin-2 (IL-2) is a polypeptide secreted by antigen or mitogen-actuated T lymphocytes that functions as a growth factor for T cells.

Localization (secreted) of Interleukin-2 in T cells

8) Confidence 0.78 Published 1991 Journal Headache Section Abstract Doc Link 1860789 Disease Relevance 0.62 Pain Relevance 0.62

The method used to detect CD4 and CD8 T cell responsiveness by secretion of Interleukin-2 (IL-2) and/or IFN-?

Localization (secretion) of Interleukin-2 in T cell

9) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943475 Disease Relevance 0.39 Pain Relevance 0.04

The immunomodulatory capacity of these compounds was evaluated by determining the interleukin-2 (IL-2) release in mitogen activated PBMC.

Localization (release) of interleukin-2 in PBMC

10) Confidence 0.77 Published 2004 Journal Life Sci. Section Abstract Doc Link 15102522 Disease Relevance 0.09 Pain Relevance 0.53

The immunomodulatory capacity of these compounds was evaluated by determining the interleukin-2 (IL-2) release in mitogen activated PBMC.

Localization (release) of IL-2 in PBMC

11) Confidence 0.77 Published 2004 Journal Life Sci. Section Abstract Doc Link 15102522 Disease Relevance 0.09 Pain Relevance 0.53

In the PCA patients, IL-2 was decreased in group M and increased in group F postoperatively.

Localization (decreased) of IL-2

12) Confidence 0.75 Published 2006 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17120754 Disease Relevance 0 Pain Relevance 1.31

They each received up to 8 subcutaneous injections of a vaccine combining lymphotactin--and interleukin-2 (IL-2)--secreting autologous neuroblastoma cells in a dose-escalating scheme.

Localization (secreting) of interleukin-2 associated with neuroblastoma

13) Confidence 0.74 Published 2007 Journal J. Immunother. Section Abstract Doc Link 17471169 Disease Relevance 0.84 Pain Relevance 0.17

They each received up to 8 subcutaneous injections of a vaccine combining lymphotactin--and interleukin-2 (IL-2)--secreting autologous neuroblastoma cells in a dose-escalating scheme.

Localization (secreting) of IL-2 associated with neuroblastoma

14) Confidence 0.74 Published 2007 Journal J. Immunother. Section Abstract Doc Link 17471169 Disease Relevance 0.84 Pain Relevance 0.17

Phase I trial of vaccination with autologous neuroblastoma tumor cells genetically modified to secrete IL-2 and lymphotactin.

Localization (secrete) of IL-2 associated with neuroblastoma and cancer

15) Confidence 0.74 Published 2007 Journal J. Immunother. Section Title Doc Link 17471169 Disease Relevance 0.86 Pain Relevance 0.17

The T-helper 1 cells, that secrete interleukin-2 and interferon-gamma for example, are reduced in activity while the T-helper 2 cells, together with the macrophages, show an increased secretion of interleukins-6 and -10.

Localization (secrete) of interleukin-2 in macrophages

16) Confidence 0.73 Published 2005 Journal Expert Rev Clin Immunol Section Abstract Doc Link 20477658 Disease Relevance 0.99 Pain Relevance 0.14

T cells were cultured for 4 days in the presence of rIL-2 (1.5ng/ml) and either rIL-12 (8ng/ml) plus anti-IL-4 mAb (10µg/ml) for Th1-polarizing conditions or rIL-4 (20ng/ml) plus anti-IFN?

Localization (presence) of IL-2 in T cells

17) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.03

[Pharmacokinetics and toxicity of intrathecal administration of recombinant interleukin 2].

Localization (administration) of interleukin 2 associated with toxicity and intrathecal

18) Confidence 0.73 Published 1986 Journal Gan To Kagaku Ryoho Section Title Doc Link 3488031 Disease Relevance 0.66 Pain Relevance 0.25

A single HVLA manipulation to the thoracic spine of asymptomatic subjects causes a significant enhancement in IL-2 secretion by PBMCs in vitro.

Localization (secretion) of IL-2 in spine

19) Confidence 0.70 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.06 Pain Relevance 0.06

Compared with VC and their respective baselines, SPA-induced secretion of IL-2 increased significantly in cultures established from both SMT-C and SMT-NC subjects at 20 min post-intervention.

Localization (secretion) of IL-2

20) Confidence 0.70 Published 2008 Journal Chiropr Osteopat Section Abstract Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0.05

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