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Context Info
Confidence 0.08
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.91
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Parp1) nuclear envelope (Parp1) intracellular (Parp1)
DNA binding (Parp1) protein complex (Parp1) nucleolus (Parp1)
Anatomy Link Frequency
cleavage 2
Parp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sSRI 8 98.28 Very High Very High Very High
fluoxetine 1 83.36 Quite High
depression 1 74.64 Quite High
antidepressant 1 68.16 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 3 98.64 Very High Very High Very High
Epstein-barr Virus 6 93.96 High High
Death 1 78.16 Quite High
Anxiety Disorder 1 75.56 Quite High
Depression 1 74.64 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resultant SSRI-induced apoptosis was preceded by caspase activation, poly(ADP-ribose) polymerase-1 (PARP-1) cleavage, DNA fragmentation, a loss of mitochondrial membrane potential, and the externalization of phosphatidylserine, and reversed by the overexpression of bcl-2.
Negative_regulation (loss) of Protein_catabolism (cleavage) of PARP-1 in cleavage associated with apoptosis and ssri
1) Confidence 0.08 Published 2003 Journal Blood Section Abstract Doc Link 12515726 Disease Relevance 0.91 Pain Relevance 0.47

General Comments

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