INT107702

Context Info Confidence 0.04 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.32 Pain Relevance 0.75

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX) plasma membrane (DCSTAMP) cytoplasm (CPOX)

Anatomy Link Frequency HASM 2 DCSTAMP (Homo sapiens) CPOX (Homo sapiens)

Pain Link Frequency Relevance Heat COX-2 inhibitor 2 98.90 cINOD 12 88.24 dexamethasone 2 61.84 COX2 2 25.00

Disease Link Frequency Relevance Heat INFLAMMATION 4 87.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, PGE(2) also induced and enhanced IL-1beta-induced COX-2 expression.

IL-1beta-induced Positive_regulation (induced) of Gene_expression (expression) of COX

1) Confidence 0.04 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.15 Pain Relevance 0.39

We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.

IL-1beta-induced Positive_regulation (induced) of Gene_expression (expression) of COX in HASM associated with cox-2 inhibitor

2) Confidence 0.04 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.16 Pain Relevance 0.36

General Comments

This test has worked.