INT107737

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 0.33
Pain Relevance 6.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Pld2) plasma membrane (Pld2) nucleus (Pld2)
Pld2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 9 99.82 Very High Very High Very High
opioid receptor 52 99.80 Very High Very High Very High
Enkephalin 10 99.76 Very High Very High Very High
agonist 57 99.32 Very High Very High Very High
Kinase C 18 99.32 Very High Very High Very High
Morphine 20 99.24 Very High Very High Very High
tolerance 1 94.08 High High
methadone 4 47.28 Quite Low
Buprenorphine 4 28.08 Quite Low
Oxycodone 4 25.36 Quite Low
Disease Link Frequency Relevance Heat
Stress 4 93.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, heterologous stimulation of PLD2 by phorbol ester led to an accelerated internalization of the mu-opioid receptor after both DAMGO and morphine exposure.
Positive_regulation (stimulation) of PLD2 associated with opioid receptor and morphine
1) Confidence 0.67 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.79
ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis.
Positive_regulation (activation) of phospholipase D2 associated with agonist and opioid receptor
2) Confidence 0.67 Published 2003 Journal J. Biol. Chem. Section Title Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.47
Treatment with the mu receptor agonist DAMGO ([d-Ala(2), Me Phe(4), Glyol(5)]enkephalin) led to an increase in PLD2 activity, whereas morphine, which does not induce MOR1 receptor internalization, failed to induce PLD2 activation.
Positive_regulation (increase) of PLD2 associated with agonist, enkephalin and morphine
3) Confidence 0.67 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.64
We have recently shown that the activation of the rat mu-opioid receptor (MOPr, also termed MOR1) by the mu-agonist [D-Ala(2), Me Phe(4), Glyol(5)]enkephalin (DAMGO) leads to an increase in phospholipase D2 (PLD2) activity and an induction of receptor endocytosis, whereas the agonist morphine which does not induce opioid receptor endocytosis fails to activate PLD2.
Positive_regulation (increase) of phospholipase D2 associated with agonist, enkephalin, opioid receptor and morphine
4) Confidence 0.65 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19519662 Disease Relevance 0.08 Pain Relevance 0.48
We have recently shown that the activation of the rat mu-opioid receptor (MOPr, also termed MOR1) by the mu-agonist [D-Ala(2), Me Phe(4), Glyol(5)]enkephalin (DAMGO) leads to an increase in phospholipase D2 (PLD2) activity and an induction of receptor endocytosis, whereas the agonist morphine which does not induce opioid receptor endocytosis fails to activate PLD2.
Positive_regulation (increase) of PLD2 associated with agonist, enkephalin, opioid receptor and morphine
5) Confidence 0.65 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19519662 Disease Relevance 0.08 Pain Relevance 0.48
Treatment with the mu receptor agonist DAMGO ([d-Ala(2), Me Phe(4), Glyol(5)]enkephalin) led to an increase in PLD2 activity, whereas morphine, which does not induce MOR1 receptor internalization, failed to induce PLD2 activation.
Neg (failed) Positive_regulation (induce) of PLD2 associated with agonist, enkephalin and morphine
6) Confidence 0.48 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.69
The DAMGO-mediated PLD2 activation was inhibited by brefeldin A, an inhibitor of ADP-ribosylation factor (ARF) but not by the protein kinase C (PKC) inhibitor calphostin C indicating that opioid receptor-mediated activation of PLD2 is ARF- but not PKC-dependent.
Positive_regulation (activation) of PLD2 associated with kinase c and opioid receptor
7) Confidence 0.48 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.70
We report here that MOPr-mediated activation of PLD2 stimulates production of reactive oxygen molecules via NADH/NADPH oxidase.
Positive_regulation (activation) of PLD2
8) Confidence 0.47 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19519662 Disease Relevance 0.09 Pain Relevance 0.54
We have recently shown that the activation of the rat mu-opioid receptor (MOPr, also termed MOR1) by the mu-agonist [D-Ala(2), Me Phe(4), Glyol(5)]enkephalin (DAMGO) leads to an increase in phospholipase D2 (PLD2) activity and an induction of receptor endocytosis, whereas the agonist morphine which does not induce opioid receptor endocytosis fails to activate PLD2.
Neg (fails) Positive_regulation (activate) of PLD2 associated with agonist, enkephalin, opioid receptor and morphine
9) Confidence 0.47 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19519662 Disease Relevance 0.09 Pain Relevance 0.52
The DAMGO-mediated PLD2 activation was inhibited by brefeldin A, an inhibitor of ADP-ribosylation factor (ARF) but not by the protein kinase C (PKC) inhibitor calphostin C indicating that opioid receptor-mediated activation of PLD2 is ARF- but not PKC-dependent.
Positive_regulation (activation) of PLD2 associated with kinase c and opioid receptor
10) Confidence 0.45 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.78
We demonstrated recently that opioid-induced activation of phospholipase D2 (PLD2) enhances mu- (MOPr) and delta-opioid receptor endocytosis/recycling and thus reduces the development of opioid receptor desensitization and tolerance.
Positive_regulation (activation) of phospholipase D2 associated with tolerance, opioid receptor and opioid
11) Confidence 0.06 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20354103 Disease Relevance 0 Pain Relevance 0.36

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