INT107779

Context Info Confidence 0.30 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 2.99 Pain Relevance 0.66

peptidase activity (F7) extracellular space (F7) extracellular region (F7) plasma membrane (F7)

Anatomy Link Frequency liver 1 F7 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 10 99.24 Inflammation 36 46.28 Bioavailability 19 5.00 Inflammatory marker 4 5.00 alcohol 4 5.00 drug abuse 3 5.00 tolerance 3 5.00 Pain 2 5.00 Bile 2 5.00 peptic ulcer disease 2 5.00

Disease Link Frequency Relevance Heat Coagulation Disorder 2 96.24 Cirrhosis 7 94.20 Congenital Anomalies 2 93.92 Hemostatic Disorders 1 93.44 Coronary Artery Disease 2 92.56 Burns 64 90.24 Injury 59 90.04 Liver Disease 60 89.08 Arrhythmias 2 Under Development 1 79.24 Adhesions 4 75.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Factor VII activity decreased from 29.4% before acetaminophen therapy to 15.5% when his INR was 6.4, and factor X activity fell from 27.0% to 20.2%.

Negative_regulation (decreased) of Factor VII associated with paracetamol

1) Confidence 0.30 Published 2003 Journal Pharmacotherapy Section Abstract Doc Link 12523469 Disease Relevance 0.08 Pain Relevance 0.66

The liver produces most of the factors involved in coagulation and fibrinolysis that helps maintain the balance between thrombin deposition and removal.38 Patients with cirrhosis frequently experience hemostatic disorders caused by abnormalities of platelet number and/or function, increased fibrinolysis, and deficient synthesis of clotting factors.38 Clotting factor deficiencies develop with the loss of functioning liver paranchymal cells, with early deficits in the Vitamin K–dependent factors (II, VII, IX, X, protein S, and protein C).38 The loss of factor VII significantly interferes with the function of the extrinsic coagulation cascade.38 Hemorrhagic complication is a major concern in patients with cirrhosis undergoing surgical interventions39 and must be considered when preparing a patient with burn injury with preexisting liver disease for surgery.

Negative_regulation (loss) of factor VII in liver associated with liver disease, coagulation disorder, cirrhosis, burns, congenital anomalies, injury and hemostatic disorders

2) Confidence 0.05 Published 2007 Journal J Burns Wounds Section Body Doc Link PMC1892842 Disease Relevance 1.83 Pain Relevance 0

Virgin olive oil containing a high content (400 mg/kg) of phenolic compounds has been demonstrated to also decrease plasminogen activator inhibitor-1 (PAI-1) and factor VII (FVII).

Negative_regulation (decrease) of factor VII

3) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852848 Disease Relevance 0.52 Pain Relevance 0

Virgin olive oil containing a high content (400 mg/kg) of phenolic compounds has been demonstrated to also decrease plasminogen activator inhibitor-1 (PAI-1) and factor VII (FVII).

Negative_regulation (decrease) of FVII

4) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852848 Disease Relevance 0.57 Pain Relevance 0

General Comments

This test has worked.