INT107922

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 9.32
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3)
mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)
Anatomy Link Frequency
endothelial cells 6
neutrophils 4
muscle 2
HeLa 2
NOS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 13 99.74 Very High Very High Very High
antagonist 4 98.98 Very High Very High Very High
Inflammatory response 10 90.76 High High
Glutamate 6 88.16 High High
Inflammation 98 87.92 High High
tolerance 46 81.04 Quite High
bradykinin 25 74.24 Quite High
cINOD 70 66.40 Quite High
COX-2 inhibitor 7 65.48 Quite High
Angina 11 57.64 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 39 99.84 Very High Very High Very High
Cv Unclassified Under Development 19 99.74 Very High Very High Very High
Nicotine Addiction 20 97.52 Very High Very High Very High
Diabetes Mellitus 517 97.44 Very High Very High Very High
Adhesions 41 97.40 Very High Very High Very High
Metabolic Syndrome 63 96.80 Very High Very High Very High
Targeted Disruption 14 96.36 Very High Very High Very High
Hyperlipidemia 19 96.08 Very High Very High Very High
Hyperglycemia 62 95.84 Very High Very High Very High
Osteoporosis 42 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experimental studies support an important role for eNOS in the regulation of angiogenesis [4]: mice lacking eNOS gene have severely reduced angiogenesis in response to tissue ischemia [5,6] while eNOS overexpression enhances angiogenesis [7-9].
Positive_regulation (overexpression) of Gene_expression (overexpression) of eNOS associated with ischemia
1) Confidence 0.60 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.56 Pain Relevance 0.15
HeLa cells transfected with NOS-3 exhibited an increase in NO biosynthesis following aspirin exposure, and this was associated with acetylation of the enzyme on both serine-765 and serine-771.
Positive_regulation (transfected) of Gene_expression (transfected) of NOS-3 in HeLa
2) Confidence 0.44 Published 2009 Journal Cardiovasc. Res. Section Body Doc Link 19377066 Disease Relevance 0 Pain Relevance 0
There is thus strong experimental evidence to support an important role for eNOS in the regulation of angiogenesis in animal models, however the implication of eNOS activity in collateral vessel formation in response to myocardial ischemia in humans remains unknown
Positive_regulation (response) of Gene_expression (activity) of eNOS associated with coronary artery disease and ischemia
3) Confidence 0.44 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.58 Pain Relevance 0.17
Endothelial nitric oxide synthase (eNOS) gene expression was increased by 67% ± 19% (p = 0.002) and 66% ± 16% (p = 0.039) in the CR and CREX groups, respectively (Figure 1D).
Positive_regulation (increased) of Gene_expression (expression) of eNOS
4) Confidence 0.43 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.08 Pain Relevance 0
Consistently, eNOS gene expression was increased in both intervention groups, suggesting an important role of eNOS in mitochondrial biogenesis in human muscle.
Positive_regulation (increased) of Gene_expression (expression) of eNOS in muscle
5) Confidence 0.43 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.09 Pain Relevance 0
This gene polymorphism could interact with the environment to produce an even more defective eNOS enzyme with increasing endothelial cell dysfunction.
Positive_regulation (increasing) of Gene_expression (produce) of eNOS in endothelial cell
6) Confidence 0.40 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.53 Pain Relevance 0
This endogenously produced competitive inhibitor of L-arginine (as well as an endogenous inhibitor of the eNOS reaction) would cause the eNOS reaction to uncouple and become a net producer of superoxide even before the glucose becomes elevated, thus stressing the islet and the intima before hyperglycemia is detected.
Positive_regulation (cause) of Gene_expression (producer) of eNOS associated with hyperglycemia
7) Confidence 0.40 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.22 Pain Relevance 0.08
1-receptor antagonist properties, nebivolol also activates eNOS and may stimulate the expression of eNOS, leading to increased NO production.
Spec (may) Positive_regulation (stimulate) of Gene_expression (expression) of eNOS associated with antagonist
8) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582806 Disease Relevance 0.47 Pain Relevance 0.28
Pathological increases in cellular NO levels due to an increase in iNOS expression or overactivation of eNOS and nNOS result in the formation of peroxynitrite (ONOO-) radical [67].
Positive_regulation (increase) of Gene_expression (expression) of eNOS
9) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.13 Pain Relevance 0
The AT1-R and eNOS colocalize in the fetoplacental endothelial cells, and the AT1-R has been shown to mediate the Ang II increases in eNOS protein expression and NO production[96].
Positive_regulation (increases) of Gene_expression (expression) of eNOS in endothelial cells
10) Confidence 0.24 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.25 Pain Relevance 0
Second, insulin is a vasodilator stimulating expression of eNOS through the phosphatidylinositol 3-kinase (PI3K) pathway (Zeng et al 2000).
Positive_regulation (stimulating) of Gene_expression (expression) of eNOS
11) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.77 Pain Relevance 0.08
Another study has revealed that eNOS upregulation induced by RGZ may
Positive_regulation (induced) of Gene_expression (upregulation) of eNOS
12) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.35 Pain Relevance 0
Statins have been shown to increase the expression and activity of the eNOS gene and to inhibit eNOS-induced osteogenesis in the mouse calvaria system.
Positive_regulation (increase) of Gene_expression (expression) of eNOS gene
13) Confidence 0.15 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193734 Disease Relevance 0.33 Pain Relevance 0
PPAR- is expressed in endothelial cells, and its ligands have been reported to enhance NO production, possibly by stimulating the PI3K pathway and hence expression of eNOS (Kim et al 2002).
Positive_regulation (stimulating) of Gene_expression (expression) of eNOS in endothelial cells
14) Confidence 0.15 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.89 Pain Relevance 0.07
In this program, Bloch et al were able to show the activation of the NO-producing enzymes eNOS and iNOS, as well as the formation of free radicals and radical reaction products.
Positive_regulation (activation) of Gene_expression (producing) of eNOS
15) Confidence 0.06 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.64 Pain Relevance 0.05
One year of treatment with perindopril upregulated eNOS protein expression and activity (19% and 27% vs placebo; p < 0.05).
Positive_regulation (upregulated) of Gene_expression (expression) of eNOS
16) Confidence 0.06 Published 2009 Journal Drugs Section Abstract Doc Link 19275271 Disease Relevance 1.29 Pain Relevance 0.16
CONCLUSION: Patients taking aspirin before UA showed a lower systemic inflammatory response and higher eNOS protein expression in their neutrophils


Positive_regulation (higher) of Gene_expression (expression) of eNOS in neutrophils
17) Confidence 0.04 Published 2002 Journal Eur. J. Clin. Invest. Section Body Doc Link 12534448 Disease Relevance 0.06 Pain Relevance 0
The eNOS protein expression was also higher in neutrophils from the UA patients taking aspirin than in those not taking aspirin.
Positive_regulation (higher) of Gene_expression (expression) of eNOS in neutrophils
18) Confidence 0.04 Published 2002 Journal Eur. J. Clin. Invest. Section Body Doc Link 12534448 Disease Relevance 0.07 Pain Relevance 0

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