INT108085

Context Info Confidence 0.53 First Reported 2003 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.58 Pain Relevance 0.75

nucleus (AKR1C3) intracellular (AKR1C3) cytoplasm (AKR1C3)

Anatomy Link Frequency HL-60 2 myeloid cells 2 AKR1C3 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 11 94.88 antagonist 1 25.00

Disease Link Frequency Relevance Heat INFLAMMATION 4 93.64 Leukemia 1 90.16 Cancer 3 85.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We have demonstrated previously that overexpression of AKR1C3 acts to suppress cell differentiation and promote proliferation in myeloid cells.

Positive_regulation (overexpression) of Gene_expression (overexpression) of AKR1C3 in myeloid cells

1) Confidence 0.53 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14996743 Disease Relevance 0.32 Pain Relevance 0.49

Here, we demonstrate that overexpression of AKR1C3 reciprocally desensitizes HL-60 cells to ATRA and D3, thus confirming the enzyme as a novel regulator of cell differentiation.

Positive_regulation (overexpression) of Gene_expression (overexpression) of AKR1C3 in HL-60

2) Confidence 0.41 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12543809 Disease Relevance 0.26 Pain Relevance 0.26

General Comments

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