INT108324

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Context Info
Confidence 0.06
First Reported 2003
Last Reported 2003
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.43
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)
Anatomy Link Frequency
endothelial cell 2
Ctnnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1 99.64 Very High Very High Very High
Inflammation 2 90.60 High High
cINOD 3 62.84 Quite High
COX2 1 25.00 Low Low
COX-2 inhibitor 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 7 100.00 Very High Very High Very High
INFLAMMATION 3 90.60 High High
Metastasis 2 88.92 High High
Colon Cancer 9 75.00 Quite High
Familial Adenomatous Polyposis 1 66.56 Quite High
Adenoma 1 64.64 Quite High
Malignant Neoplastic Disease 1 25.00 Low Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical analyses of the primary splenic tumor in rofecoxib-treated mice showed no alteration in COX-1 expression, but significant decreases in the expression of the tumor-promoting proteins COX-2, cyclin D1, cytosolic beta-catenin, matrix metalloproteinases-2 and -9, and vascular endothelial cell- derived growth factor.
Neg (no) Negative_regulation (decreases) of Gene_expression (expression) of cytosolic beta-catenin in endothelial cell associated with cancer and metalloproteinase
1) Confidence 0.06 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566300 Disease Relevance 1.43 Pain Relevance 0.31

General Comments

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