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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.85
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF, MAPK1) nucleoplasm (MAPK1) mitochondrion (MAPK1)
Golgi apparatus (MAPK1) DNA binding (MAPK1) protein complex (MAPK1)
Anatomy Link Frequency
colon 2
EGF (Homo sapiens)
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 36 91.64 High High
imagery 1 88.68 High High
cytokine 60 85.76 High High
agonist 1 73.20 Quite High
COX2 2 70.92 Quite High
Inflammation 19 50.00 Quite Low
Immobilon 2 48.80 Quite Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 31 99.68 Very High Very High Very High
Lung Cancer 62 92.16 High High
INFLAMMATION 31 91.40 High High
Apoptosis 39 88.88 High High
Cancer 33 88.08 High High
Death 13 76.88 Quite High
Rectal Cancer 1 74.96 Quite High
Small Cell Lung Carcinoma 1 61.08 Quite High
Malignant Neoplastic Disease 8 59.64 Quite High
Prostate Cancer 27 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EGF-stimulated phosphorylation of ERK and Bad is blocked by pretreatment with U0126, a selective MAP kinase kinase (MKK)1/2 inhibitor.
EGF Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of ERK
1) Confidence 0.48 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566304 Disease Relevance 1.33 Pain Relevance 0.16
EGF stimulated phosphorylation of ERK in the range of OSM, while insulin was minimally effective.
EGF Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of ERK
2) Confidence 0.45 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.17 Pain Relevance 0.21
EGF induces phosphorylation of EGFR and ERK1/2 in HT29 human colon cancer cells
EGF Positive_regulation (induces) of Phosphorylation (phosphorylation) of ERK1/2 in colon associated with colon cancer
3) Confidence 0.11 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.18 Pain Relevance 0.04
Interestingly, in Ist-Mes-2 cells, EGF stimulation induced EGFR phosphorylation as expected, but did not induce AKT and ERK phosphorylation, suggesting other possible signalling pathways of EGFR.

EGF Neg (not) Positive_regulation (induce) of Phosphorylation (phosphorylation) of ERK
4) Confidence 0.04 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.16 Pain Relevance 0.04
Growth factor dependent MAPK activation was constrained by dynamic measurements of phosphorylated ERK (ERKpp) levels following stimulation of EGFR with 8nM EGF (Fig. 5D).
EGF Positive_regulation (stimulation) of Phosphorylation (phosphorylated) of ERK
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

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