INT108336

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Context Info
Confidence 0.80
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 41
Total Number 93
Disease Relevance 22.25
Pain Relevance 8.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EPHB2)
Anatomy Link Frequency
L929 9
colon 2
HeLa 2
SW480 1
chondrocytes 1
EPHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 24 99.72 Very High Very High Very High
bradykinin 24 99.62 Very High Very High Very High
Morphine 20 99.60 Very High Very High Very High
cINOD 22 99.58 Very High Very High Very High
Immobilon 65 99.46 Very High Very High Very High
Glutamate 5 99.04 Very High Very High Very High
Kinase C 348 98.76 Very High Very High Very High
Osteoarthritis 66 98.24 Very High Very High Very High
Delta opioid receptors 16 95.48 Very High Very High Very High
cytokine 259 94.04 High High
Disease Link Frequency Relevance Heat
Colon Cancer 56 99.60 Very High Very High Very High
INFLAMMATION 156 99.46 Very High Very High Very High
Epilepsy 107 99.12 Very High Very High Very High
Cancer 1270 98.68 Very High Very High Very High
Osteoarthritis 67 98.24 Very High Very High Very High
Apoptosis 203 97.88 Very High Very High Very High
Immunization 60 97.24 Very High Very High Very High
Endometriosis (extended) 14 97.20 Very High Very High Very High
Thyroid Neoplasm 179 97.18 Very High Very High Very High
Death 36 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, effects of VPA on the degree of Erk1/2 phosphorylation and HDAC inhibition seem to be independent responses that, subsequently, may modulate biological processes such as cell growth or motility through independent mechanisms.
Phosphorylation (phosphorylation) of Erk1
1) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.13 Pain Relevance 0
In the presence of minimal amounts EPO, we also found increased Erk1/2 phosphorylation, which suggests greatly augmented activity of the receptor (Figure 6B).
Phosphorylation (phosphorylation) of Erk1
2) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.06 Pain Relevance 0.04
1A-AR-antibodies result in protein kinase C alpha activation and transient extracellular-related kinase (ERK1/2) phosphorylation.
Phosphorylation (phosphorylation) of ERK1 associated with kinase c
3) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.45 Pain Relevance 0.09
Growth factor dependent MAPK activation was constrained by dynamic measurements of phosphorylated ERK (ERKpp) levels following stimulation of EGFR with 8nM EGF (Fig. 5D).
Phosphorylation (phosphorylated) of ERK
4) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0
Therefore, a potential relationship between the effects of VPA on the degree of Erk1/2 phosphorylation and cell motility was investigated further in L929 cells.
Phosphorylation (phosphorylation) of Erk1 in L929
5) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
However, cell lines demonstrating significant changes in the degree of Erk1/2 phosphorylation in response to VPA, generally had lower IC50 values for growth than cell lines with unaffected degrees of Erk1/2 phosphorylation (pERK-change, p < 0.05 and growth IC50 >3 mM, 0 cell lines; pERK-change, p < 0.05 and growth IC50 <3 mM, 5 cell lines; pERK-change, p > 0.05 and growth IC50 <3 mM, 4 cell lines; pERK-change, p > 0.05 and growth IC50 >3 mM, 1 cell line; p < 0.05; ?
Phosphorylation (phosphorylation) of Erk1
6) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
We have shown activation of the EP2 and FP receptors can lead to phosphorylation of ERK1/2 via the activation of c-Src and transphosphorylation of the epidermal growth factor receptor (EGFR) in Ishikawa cells and endometrial adenocarcinoma explants ex vivo [7,18].
Phosphorylation (phosphorylation) of ERK1 associated with endometriosis (extended)
7) Confidence 0.80 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.45 Pain Relevance 0.13
A comparison of Figure 3a and 3d revealed that the time-course of the effects of VPA on the degree of Erk1/2 phosphorylation resembled that observed for the inhibition of cell speed, suggesting that VPA partially modulated cell speed through modulation of the degree of Erk1/2 phosphorylation.
Phosphorylation (phosphorylation) of Erk1
8) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
Finally, no relationship was found between the effects of VPA on HDAC inhibition and the degree of Erk1/2 phosphorylation.
Phosphorylation (phosphorylation) of Erk1
9) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
In L929 cells, VPA inhibits the degree of Erk1/2 phosphorylation (Figure 1) and cell speed [21].
Phosphorylation (phosphorylation) of Erk1 in L929
10) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
Therefore, a direct correlation between changes in the degree of Erk1/2 phosphorylation and the cell speed is not to be expected and was not observed (Additional file 1, Figure S4).
Phosphorylation (phosphorylation) of Erk1
11) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
After 6 and 24 h, the degree of Erk1/2 phosphorylation decreased further.
Phosphorylation (phosphorylation) of Erk1
12) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
These results demonstrate that exposure to VPA reversed the effects of caRas expression on L929 cell morphology and the degree of Erk1/2 phosphorylation.
Phosphorylation (phosphorylation) of Erk1 in L929
13) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
Furthermore, the effects of VPA on the degree of Erk1/2 phosphorylation and HDAC inhibition were not related to the degree of Erk1/2 phosphorylation and acetylation in the absence of the drug.
Phosphorylation (phosphorylation) of Erk1
14) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
Consequently, cell type-specific effects of VPA on the degree of Erk1/2 phosphorylation may be partially explained by cell type-specific differences in the expression of Raf isoforms.
Phosphorylation (phosphorylation) of Erk1
15) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.06 Pain Relevance 0.05
Figure 3d and 3f show dose-response curves of the effects of VPA on Erk1/2 phosphorylation.
Phosphorylation (phosphorylation) of Erk1
16) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
In conclusion, VPA has highly cell type-specific effects on the degree of HDAC inhibition and on changes in the degree of Erk1/2 phosphorylation.
Phosphorylation (phosphorylation) of Erk1
17) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
These results demonstrate a significant relationship between the effects of VPA o the degree of Erk1/2 phosphorylation and cell growth (p < 0.05, Fisher's exact test).
Phosphorylation (phosphorylation) of Erk1
18) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
For estimation of Erk1/2 phosphorylation, membranes were probed with anti-phospho-Erk1/2 (Thr202/Tyr204) antibody (Cell Signaling).
Phosphorylation (phosphorylation) of Erk1
19) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0.04
Furthermore, the effects of VPA on the degree of Erk1/2 phosphorylation and HDAC inhibition were not related to the degree of Erk1/2 phosphorylation and acetylation in the absence of the drug.
Phosphorylation (phosphorylation) of Erk1
20) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0

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