INT10834

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Context Info
Confidence 0.48
First Reported 1992
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 65
Total Number 66
Disease Relevance 41.66
Pain Relevance 16.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
neutrophil 10
endothelial cells 3
tear 2
lymph node 2
saliva 2
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1452 100.00 Very High Very High Very High
Inflammation 1366 100.00 Very High Very High Very High
cytokine 965 100.00 Very High Very High Very High
Somatostatin 3 100.00 Very High Very High Very High
Inflammatory response 148 99.96 Very High Very High Very High
Inflammatory mediators 41 99.52 Very High Very High Very High
antagonist 113 99.48 Very High Very High Very High
corticosteroid 25 99.30 Very High Very High Very High
narcan 33 99.24 Very High Very High Very High
Osteoarthritis 156 98.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1591 100.00 Very High Very High Very High
Cancer 621 100.00 Very High Very High Very High
Necrosis 63 100.00 Very High Very High Very High
Delirium 13 100.00 Very High Very High Very High
Nasopharynx Cancer 4 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 35 99.90 Very High Very High Very High
Congenital Anomalies 17 99.88 Very High Very High Very High
Animal Disease Models 19 99.28 Very High Very High Very High
Lung Cancer 146 99.22 Very High Very High Very High
Malignant Neoplastic Disease 28 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant association between IL-8 (-251) A allele and large tumor size (T3-T4), high SBR tumor grade (grade 3), and lymph node metastases was observed (Table 6).
IL-8 Binding (association) of in lymph node associated with cancer and metastasis
1) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.18 Pain Relevance 0
Interestingly, we observed a significant association between IL-8 (-251) A allele and a negative hormonal status (P = 0.0008).
IL-8 Binding (association) of
2) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.09 Pain Relevance 0
A schematic showing different forms of CXCL8 and their interactions for neutrophil recruitment is shown in Figure 8.
CXCL8 Binding (interactions) of in neutrophil
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.53 Pain Relevance 0.19
The only studies on GAG-bound chemokine in which CXCL8 activity was measured with and without adding soluble GAG in cell-based assays were inconclusive and contradictory with one study showing soluble GAG enhances CXCL8 binding and the other showing reduced binding [40], [41].
CXCL8 Binding (binding) of associated with chemokine
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.15
CXCL8 binds its receptors with nanomolar (nM) affinity, and we had shown that a trapped CXCL8 monomer and WT CXCL8 have similar receptor binding activities [10].
CXCL8 Binding (binds) of
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.12
Conflicting results on the association of IL-8 and the degree of inflammation have been also reported previously.
IL-8 Binding (association) of associated with inflammation
6) Confidence 0.38 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2874215 Disease Relevance 0.38 Pain Relevance 0.19
The assessment of the prognostic value of IL-8 genetic marker in breast carcinoma confirmed the results of our previous study and indicated that IL-8 (-251) A allele is highly associated with aggressive forms of breast carcinoma as defined by large tumor size, high grade and lymph node metastases.
IL-8 Binding (associated) of in lymph node associated with cancer, breast cancer and metastasis
7) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.98 Pain Relevance 0
These in vitro results suggest inflammation of gestational tissues in vivo may result in locally produced IL-8 and, in association with other inflammatory mediators, may be important in the pathophysiology of infection-induced labor.
IL-8 Binding (association) of associated with inflammatory mediators, inflammation and infection
8) Confidence 0.37 Published 1992 Journal J. Cell. Physiol. Section Abstract Doc Link 1522134 Disease Relevance 0.88 Pain Relevance 0.39
Additional pro-angiogenic molecules and growth factors that are synthesized by MM cell lines and clinical specimens are interleukin-8 (IL-8) (Galffy, 1999; Davidson, 2004), bFGF (Strizzi, 2001b; Davidson, 2004), TGF-?
IL-8 Binding (interleukin-8) of associated with lung cancer
9) Confidence 0.36 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 0.49 Pain Relevance 0
The sensitivities of the test kits were as follows: IL-8: 1.5 pg/mL and TNF-?
IL-8 Binding (were) of
10) Confidence 0.35 Published 2010 Journal Crit Care Section Body Doc Link PMC2887148 Disease Relevance 0.16 Pain Relevance 0.09
The risk associated with IL8:rs4073 was similar at 3.16-fold (95% CI:1.54–6.48).
IL8 Binding (associated) of
11) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.83 Pain Relevance 0.12
In order to determine whether rates of CXCL8 trafficking could influence recruitment, we determined CXCL8 levels in sera and BALF.
CXCL8 Binding (trafficking) of
12) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.08 Pain Relevance 0.04
Tissue trafficking of CXCL8 WT, trapped monomer, and trapped dimer were analyzed in the lung model.
CXCL8 Binding (trafficking) of in lung
13) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.26 Pain Relevance 0.06
The higher levels seen for the monomer and the WT at 4 h crudely correlates with recruitment seen for 12 h, but there is no correlation with low CXCL8 levels at 12 h and recruitment at 18 h.
CXCL8 Binding (recruitment) of
14) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.35
In particular, we show that robust neutrophil recruitment requires CXCL8 dimerization, and that the ability of CXCL8 to reversibly exist as monomers and dimers and GAG binding-mediated gradient formation play critical roles in regulating neutrophil recruitment.
CXCL8 Binding (dimerization) of in neutrophil
15) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.25 Pain Relevance 0.12
If total amount of CXCL8 directly correlates with neutrophil recruitment, the chemokine levels at 4 to 6 h should be responsible for the recruitment seen at 12 h, and levels at 12 h for recruitment seen at 18 h.
CXCL8 Binding (amount) of in neutrophil associated with chemokine
16) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.16
It is now known that WT CXCL8 dimer dissociates at µM concentrations, and so it is not surprising that it is monomeric at nanomolar concentrations used in in vitro functional studies and dimeric at millimolar concentrations used in structural studies [23].
CXCL8 dimer Binding (dissociates) of
17) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.11
CXCL8 function also involves binding to GAG on endothelial cells and the extracellular matrix, and there is evidence from in vitro and knockout animal model studies that GAG-binding promotes and facilitates formation of a concentration gradient, which is essential for directional neutrophil recruitment [31], [32].
CXCL8 Binding (binding) of in extracellular matrix associated with targeted disruption
18) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.24 Pain Relevance 0.12
During an inflammatory response, CXCL8 navigates through different compartments from its point of production and is taken up by venular endothelial cells abluminally and transcytosed to the luminal surface, where CXCL8 is immobilized on endothelial cell-surface GAGs for presentation to circulating neutrophils [9].
CXCL8 Binding (navigates) of in endothelial cell associated with inflammatory response
19) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.76 Pain Relevance 0.20
In particular, we show that robust neutrophil recruitment requires CXCL8 dimerization, and that the ability of CXCL8 to reversibly exist as monomers and dimers and GAG binding-mediated gradient formation play critical roles in regulating neutrophil recruitment.
CXCL8 Binding (binding) of in neutrophil
20) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.35 Pain Relevance 0.15

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