INT10835

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Context Info
Confidence 0.49
First Reported 1992
Last Reported 2011
Negated 11
Speculated 7
Reported most in Abstract
Documents 79
Total Number 86
Disease Relevance 53.04
Pain Relevance 24.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
monocyte 5
neutrophil 5
plasma 2
amnion 2
THP-1 2
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1029 100.00 Very High Very High Very High
cytokine 742 100.00 Very High Very High Very High
chemokine 635 100.00 Very High Very High Very High
Versed 22 100.00 Very High Very High Very High
lidocaine 15 100.00 Very High Very High Very High
Paracetamol 11 100.00 Very High Very High Very High
substance P 9 100.00 Very High Very High Very High
Inflammatory response 106 99.92 Very High Very High Very High
Inflammatory mediators 42 99.76 Very High Very High Very High
antagonist 122 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1178 100.00 Very High Very High Very High
Cancer 670 100.00 Very High Very High Very High
Disease 504 100.00 Very High Very High Very High
Asthma 363 100.00 Very High Very High Very High
Infection 296 100.00 Very High Very High Very High
Stress 171 100.00 Very High Very High Very High
Injury 92 100.00 Very High Very High Very High
Necrosis 65 100.00 Very High Very High Very High
Adenoma 37 99.84 Very High Very High Very High
Lung Cancer 5 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 2 to 4 weeks of low-dose corticosteroids and after 4 months of MTX therapy, there were no significant changes in the levels of circulating IL-8 (data not shown).
Neg (no) Regulation (changes) of IL-8 associated with corticosteroid and methotrexate
1) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.59 Pain Relevance 0.86
These data strongly suggest that the anesthetics modulate transport or secretion of IL-8 protein from the cell.
Regulation (modulate) of IL-8 protein
2) Confidence 0.45 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620522 Disease Relevance 0.14 Pain Relevance 0.37
The IL-8 gene is located on chromosome 4q13-21 and consists of four exons, three introns, and a proximal promoter region [22].
Regulation (consists) of IL-8 in proximal
3) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.62 Pain Relevance 0.32
Cytokine genes and pain severity in lung cancer: exploring the influence of TNF-alpha-308 G/A IL6-174G/C and IL8-251T/A.
Regulation (influence) of IL8 in lung associated with pain, lung cancer and cytokine
4) Confidence 0.44 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Title Doc Link 18086782 Disease Relevance 0.49 Pain Relevance 0.73
We have tested effects of SN, substance P (SP), and interleukin-8 (IL-8) on eosinophil migration in modified Boyden chambers including signaling mechanisms of neuropeptide and cytokine stimulation of human eosinophils.
Regulation (effects) of IL-8 in eosinophils associated with neuropeptide, cytokine and substance p
5) Confidence 0.43 Published 1998 Journal Blood Section Abstract Doc Link 9473216 Disease Relevance 0 Pain Relevance 0.50
We have tested effects of SN, substance P (SP), and interleukin-8 (IL-8) on eosinophil migration in modified Boyden chambers including signaling mechanisms of neuropeptide and cytokine stimulation of human eosinophils.
Regulation (effects) of interleukin-8 in eosinophils associated with neuropeptide, cytokine and substance p
6) Confidence 0.43 Published 1998 Journal Blood Section Abstract Doc Link 9473216 Disease Relevance 0 Pain Relevance 0.50
We propose GAG-bound CXCL8 dimer plays an important role in regulating the local CXCL8 concentration by functioning as a reservoir, and regulating soluble CXCL8 concentration for engagement with the receptor.
Regulation (regulating) of CXCL8 in reservoir
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.14
Our in vitro studies using the microfluidic device and our in vivo animal studies show that recruitment is not only dependent on the total amount of CXCL8, but also on the steepness of the gradient, which in turn is dependent on the continuous inter-conversion among various forms of CXCL8: free monomer and dimer and GAG-bound monomer and dimer.
Regulation (dependent) of CXCL8
8) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0
Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock.
Regulation (Effect) of interleukin-8 associated with stress and sepsis
9) Confidence 0.40 Published 2005 Journal Clin. Chem. Lab. Med. Section Title Doc Link 15843228 Disease Relevance 0.98 Pain Relevance 0.13
Combined with our results, the data indicate that the major three factors (IL-6, IL-8 and MCP-1) are critical in multiple vitreoretinal disorders including uveitis.
Regulation (critical) of IL-8 associated with uveitis
10) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780733 Disease Relevance 1.53 Pain Relevance 0.06
Activated endothelial IL-1beta, IL-6, and IL-8 concentrations and ICAM-1 expression are attenuated only by lidocaine at concentrations larger than clinically relevant concentrations.
Regulation (attenuated) of IL-8 associated with lidocaine
11) Confidence 0.33 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15673867 Disease Relevance 0.25 Pain Relevance 0.52
Essentially our data imply that tumor cells closely associated with the bone matrix may utilize HA-dependent up-regulation of IL-8, while cells located in the center of the tumor (i.e., those not in direct contact with HA) may depend on TGF?
Regulation (regulation) of IL-8 associated with cancer
12) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809751 Disease Relevance 0.75 Pain Relevance 0.08
Finally, we showed that IL-8 was also regulated by R1881 and could stimulate the expression of ARG1 and ARG2 independently of androgen.
Regulation (regulated) of IL-8
13) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 1.18 Pain Relevance 0
The effect of midazolam and propofol on interleukin-8 from human polymorphonuclear leukocytes.
Regulation (effect) of interleukin-8 in polymorphonuclear leukocytes associated with versed
14) Confidence 0.27 Published 1998 Journal Anesth. Analg. Section Title Doc Link 9620522 Disease Relevance 0.09 Pain Relevance 0.19
We investigated the effect of propofol and midazolam on interleukin-8, a neutrophil chemotactic agent in human neutrophils.
Spec (investigated) Regulation (effect) of interleukin-8 in neutrophils associated with versed
15) Confidence 0.27 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620522 Disease Relevance 0.10 Pain Relevance 0.38
Another major pro-inflammatory cytokine, IL-8, was unaffected by therapeutic concentrations of meloxicam.
Neg (unaffected) Regulation (unaffected) of IL-8 associated with inflammation and cytokine
16) Confidence 0.27 Published 1997 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 9364409 Disease Relevance 0.44 Pain Relevance 0.74
Given the importance of IL-8 and CXCR2 in angiogenesis, we investigated the relationship between polymorphisms -251 T/A in IL-8 gene and (+1208) C/T in CXCR2 gene and breast carcinoma.
Spec (investigated) Regulation (importance) of IL-8 associated with breast cancer
17) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.22 Pain Relevance 0
Amnion cell biosynthesis of interleukin-8: regulation by inflammatory cytokines.
Regulation (regulation) of interleukin-8 in Amnion associated with inflammation and cytokine
18) Confidence 0.27 Published 1992 Journal J. Cell. Physiol. Section Title Doc Link 1522134 Disease Relevance 0.75 Pain Relevance 0.40
We investigated the biosynthesis of IL-8 by human amnion cells and its regulation by other inflammatory cytokines.
Spec (investigated) Regulation (regulation) of IL-8 in amnion associated with inflammation and cytokine
19) Confidence 0.27 Published 1992 Journal J. Cell. Physiol. Section Abstract Doc Link 1522134 Disease Relevance 0.79 Pain Relevance 0.40
No relationship between IL-8 concentrations in CSF and pain intensity, positive neurological findings or a positive straight leg-raising (SLR) test was found.
Regulation (concentrations) of IL-8 in leg associated with pain
20) Confidence 0.26 Published 2002 Journal Eur Spine J Section Abstract Doc Link 11931066 Disease Relevance 0.82 Pain Relevance 0.66

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