INT108367

Context Info Confidence 0.13 First Reported 2002 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0 Pain Relevance 0.14

plasma membrane (Chrm5) cellular_component (Chrm5) signal transducer activity (Chrm5)

Anatomy Link Frequency spinal cord 1 internal 1 afferent neurons 1 Chrm5 (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 16 57.52 Enkephalin 5 56.88 calcitonin gene related peptide 3 56.20 Neurotransmitter 19 50.56 Morphine 6 50.00 Spinal cord 5 50.00 medulla 4 50.00 Calcium channel 20 5.00 excitatory amino acid 16 5.00 agonist 13 5.00

Disease Link Frequency Relevance Heat Vomiting 17 20.00 Syndrome 8 18.32 Vertigo 23 5.00 Disease 20 5.00 Nystagmus 11 5.00 Dizziness 6 5.00 Headache 5 5.00 Vestibular Diseases 4 5.00 Anxiety Disorder 4 5.00 Sleep Disorders 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The levels of m1, m2, m3 and m5 in spinal cord were increased by pretreatment with pirenzepine and the levels of m2, m3 and m4 in spinal cord were increased by pretreatment with scopolamine.

Gene_expression (levels) of m5 in spinal cord

1) Confidence 0.13 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0

METHODS: The mRNA expression level of m1, m2, m3, m4 and m5 were determined by RT-PCR, the beta-actin mRNA expression was used as internal control.

Gene_expression (expression) of m5 in internal

2) Confidence 0.06 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0

In addition to nicotinic receptors, muscarinic receptors (m1, m2 and m5) were expressed in human vestibular afferent neurons, whereas in the rat, five subtypes of muscarinic receptors (m1 - m5) are found [160].

Gene_expression (expressed) of m5 in afferent neurons

3) Confidence 0.01 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866460 Disease Relevance 0 Pain Relevance 0.14

General Comments

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