INT108556

Context Info Confidence 0.32 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 10 Disease Relevance 7.77 Pain Relevance 1.49

cytosol (BCL2L10) mitochondrion (BCL2L10) nucleus (BCL2L10)

Anatomy Link Frequency fat 1 MG-63 1 urethra 1 BCL2L10 (Homo sapiens)

Pain Link Frequency Relevance Heat local anesthetic 21 99.88 sodium channel 2 89.04 tetrodotoxin 1 86.72 COX-2 inhibitor 104 83.24 ketamine 1 80.72 anesthesia 5 80.16 Pain 7 69.40 lidocaine 2 68.80 Bile 4 58.72 Bioavailability 12 54.60

Disease Link Frequency Relevance Heat Apoptosis 385 100.00 Stress Incontinence 4 99.30 Osteogenic Sarcomas 4 98.88 Injury 9 98.72 Hepatocellular Cancer 29 97.76 Shock 9 95.96 Body Weight 11 94.56 Cancer 424 93.52 Wrinkles 1 92.88 Leukemia 22 91.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results suggest that the digestion and absorption of BOO and OOO were suppressed in the BOO group.

Negative_regulation (suppressed) of BOO

1) Confidence 0.32 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2918615 Disease Relevance 0 Pain Relevance 0

In this study, although the behenic acid content of the administered diets was relatively lower than that used in previous studies, visceral fat amounts were shown to clearly decrease in the BOO group.

Negative_regulation (decrease) of BOO in fat

2) Confidence 0.32 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2918615 Disease Relevance 0.11 Pain Relevance 0.03

These results suggest that the digestion and absorption of BOO and OOO were suppressed in the BOO group.

Negative_regulation (suppressed) of BOO

3) Confidence 0.32 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2918615 Disease Relevance 0 Pain Relevance 0

Local anesthetics also inhibited the activities of anti-apoptotic kinases protein kinase B (Akt) and extracellular signal regulated mitrogen-activated protein kinase.

Negative_regulation (inhibited) of anti-apoptotic kinases protein kinase B associated with apoptosis and local anesthetic

4) Confidence 0.21 Published 2003 Journal Am. J. Nephrol. Section Abstract Doc Link 12586958 Disease Relevance 1.21 Pain Relevance 1.07

Increased exposure time to Fan caused apoptosis of PC3 cells, which was associated with up-regulation of pro-apoptotic proteins Bax and caspase 3, and down-regulation of anti-apoptotic protein Bcl-2.

Negative_regulation (down-regulation) of anti-apoptotic protein Bcl-2 associated with apoptosis

5) Confidence 0.14 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20208355 Disease Relevance 1.23 Pain Relevance 0.07

Simultaneously with a marked increase in NF-kB activity, there is over-expression of the pro-apoptotic protein Bax, and down-regulation of the anti-apoptotic protein Bcl-2.

Negative_regulation (regulation) of anti-apoptotic protein Bcl-2 associated with apoptosis

6) Confidence 0.07 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.35 Pain Relevance 0

In addition, the decrease in the level of the anti-apoptotic protein bcl-2 would also elicit more mitochondrial injuries (Figure 5A) which facilitate the release of mitochondrial singlet oxygen to the cytosol and lead to the rapid increase of intracellular singlet oxygen concentration in Pa-PDT treated cells (Figure 3A).

Negative_regulation (decrease) of anti-apoptotic protein bcl-2 associated with injury and apoptosis

7) Confidence 0.06 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.84 Pain Relevance 0

Similarly, the sensitivity to cisplatin was increased by celecoxib in a human osteosarcoma cell line (MG-63) and this effect was linked to a down-regulation of anti-apoptotic proteins survivin, Bcl-2, and an inhibition of the survival pathway PI3K/Akt [112].

Negative_regulation (regulation) of anti-apoptotic proteins survivin in MG-63 associated with apoptosis and osteogenic sarcomas

8) Confidence 0.04 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.66 Pain Relevance 0.04

This effect was due to an upregulation of TRAIL receptors (TRAIL R2/DR5 and TRAIL-R1/DR4), together with an ability of the compounds to induce a down-regulation of the anti-apoptotic proteins survivin (IAP) and Bcl-xL [121].

Negative_regulation (regulation) of anti-apoptotic proteins survivin associated with apoptosis

9) Confidence 0.04 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.50 Pain Relevance 0.08

The implanted catheters fitted loosely around the urethra, resulting in a constant and mild degree of BOO.

Negative_regulation (degree) of BOO in urethra associated with stress incontinence

10) Confidence 0.04 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.87 Pain Relevance 0.19

General Comments

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