INT108690

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 7.20
Pain Relevance 8.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Hcn1)
Anatomy Link Frequency
neurons 5
ovary 4
oocytes 3
HCN-2 1
granulosa cells 1
Hcn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
HCN1 408 100.00 Very High Very High Very High
hCN2 84 100.00 Very High Very High Very High
Trigeminal ganglion neurons 4 99.58 Very High Very High Very High
qutenza 7 99.04 Very High Very High Very High
dorsal root ganglion 1 98.84 Very High Very High Very High
sodium channel 48 97.68 Very High Very High Very High
c fibre 12 97.64 Very High Very High Very High
Inflammation 14 96.52 Very High Very High Very High
Pain 10 95.52 Very High Very High Very High
Root ganglion neuron 16 91.28 High High
Disease Link Frequency Relevance Heat
Aging 266 100.00 Very High Very High Very High
Ganglion Cysts 43 99.96 Very High Very High Very High
Diabetes Mellitus 14 99.08 Very High Very High Very High
Nervous System Injury 3 97.36 Very High Very High Very High
INFLAMMATION 10 96.52 Very High Very High Very High
Lifespan 12 96.04 Very High Very High Very High
Pain 7 95.52 Very High Very High Very High
Syndrome 1 86.40 High High
Neuropathic Pain 3 86.00 High High
Nociception 4 82.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HCN channels, particularly HCN1, are abundantly expressed in rat primary afferent somata.
Gene_expression (expressed) of HCN1 associated with hcn1
1) Confidence 0.76 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12598605 Disease Relevance 1.22 Pain Relevance 0.86
In addition, the number of retrogradely labeled neurons from the dura expressing HCN1 and HCN2 was significantly increased to 247% (HCN1) and 171% (HCN2), three days after inflammation.
Gene_expression (expressing) of HCN1 in neurons associated with inflammation, hcn1 and hcn2
2) Confidence 0.76 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409968 Disease Relevance 0.60 Pain Relevance 1.31
HCN1 and HCN2 channel immunoreactivity was observed on the membranes of medium- to large-sized trigeminal ganglion neurons with 76% and 85% of HCN1 and HCN2 expressing neurons also containing the 200 kDa neurofilament protein (associated with myelinated fibers).
Gene_expression (expressing) of HCN1 in neurons associated with ganglion cysts, hcn1, trigeminal ganglion neurons and hcn2
3) Confidence 0.76 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409968 Disease Relevance 0.52 Pain Relevance 0.78
Compared to the sham NG neurons, diabetes induced the expression of HCN2 in the A-fiber neurons besides overexpression of HCN1 and HCN3; and enhanced the expression of HCN2 and HCN3 in C-fiber neurons.
Gene_expression (overexpression) of HCN1 in neurons associated with ganglion cysts, c fibre, diabetes mellitus, hcn1 and hcn2
4) Confidence 0.72 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.02 Pain Relevance 0.75
In the sham NG, HCN1, HCN3, and HCN4 were expressed in the A-fiber neurons; and HCN2, HCN3, and HCN4 were expressed in the C-fiber neurons.
Gene_expression (expressed) of HCN1 in neurons associated with ganglion cysts, c fibre, hcn1 and hcn2
5) Confidence 0.72 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.00 Pain Relevance 0.62
In the data presented in this report, HCN1 and HCN2 had minimal variation through the aging process, with HCN1 only exhibiting declining levels in the oocytes during reproductive aging.
Gene_expression (exhibiting) of HCN1 in oocytes associated with aging, hcn1 and hcn2
6) Confidence 0.62 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.40 Pain Relevance 0.20
After electrophoresis, the proteins were electrically transferred to a nitrocellulose membrane (VWR International, West Chester, PA), blocked with 5% skim milk in TTBS (TBS with 0.1% Tween 20), and then incubated overnight at 4°C with rabbit polyclonal antibodies against HCN1-4 (anti-HCN 1, 2, 3 or 4; product # APC-056, APC-030, APC-057, APC-052, respectively; Alomone Labs Ltd., Jerusalem, Israel) [26] at a dilution of 1:200.
Gene_expression (product) of HCN1 associated with hcn1
7) Confidence 0.62 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.14
For HCN1, HCN2, and HCN3, the proteins were found in oocytes and in the granulosa cells of primary, preantral, and antral follicles.
Gene_expression (found) of HCN1 in granulosa cells associated with hcn1 and hcn2
8) Confidence 0.62 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.41
In the data presented in this report, HCN1 and HCN2 had minimal variation through the aging process, with HCN1 only exhibiting declining levels in the oocytes during reproductive aging.
Gene_expression (exhibiting) of HCN1 in oocytes associated with aging, hcn1 and hcn2
9) Confidence 0.62 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.40 Pain Relevance 0.20
In this study, we analyzed the expression and localization of HCN1-4 in the rat ovary to assess this postulate.


Spec (analyzed) Gene_expression (expression) of HCN1 in ovary associated with hcn1
10) Confidence 0.56 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.47 Pain Relevance 0.16
HCN1-4 mRNA expression in the rat ovary was determined by RT-PCR (Figure 1A).
Gene_expression (expression) of HCN1 in ovary associated with hcn1
11) Confidence 0.56 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.22
There are decreases in the expression of HCN1, 3, and 4 in the oocytes during reproductive aging, with the decrease in HCN4 being the most pronounced.
Gene_expression (expression) of HCN1 in oocytes associated with aging and hcn1
12) Confidence 0.56 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.30 Pain Relevance 0.17
HCN1-3 are expressed in ovarian structures including oocytes, granulosa and thecal cells, and in luteal cells, while HCN 4 is only expressed in the oocytes.
Gene_expression (expressed) of HCN1 in luteal cells associated with hcn1
13) Confidence 0.56 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.43 Pain Relevance 0.18
In conclusion, HCN1-4 channels are expressed in the ovary and there are differential expression patterns for the channels.
Gene_expression (expressed) of HCN1 in ovary associated with hcn1
14) Confidence 0.56 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.42 Pain Relevance 0.17
The evidence presented here demonstrates cell-type and developmental age patterns of HCN1-4 channel expression in rat ovaries.
Gene_expression (expression) of HCN1 in ovaries associated with hcn1
15) Confidence 0.56 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2533335 Disease Relevance 0.10 Pain Relevance 0.25
Gene expression and western blot analysis of HCN1-4
Gene_expression (expression) of HCN1 associated with hcn1
16) Confidence 0.56 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.21
To visualize HCN1, 2, and 3, the Alexa Fluor was applied at a dilution of 1:1000.
Gene_expression (visualize) of HCN1 associated with hcn1
17) Confidence 0.54 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.18
The mean V1/2 values and time constants in our study are similar to native channels in thalamocortical and hippocampal neurones that express different combinations of HCN1, 2 and 4 subunits (Santoro et al., 2000; Surges et al., 2006); the V1/2 values are intermediate to values reported previously for homomeric HCN2 and HCN4 channels (Accili et al., 2002).
Gene_expression (express) of HCN1 associated with hcn1 and hcn2
18) Confidence 0.34 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0.18
At the mRNA level, HCN2 and HCN4 are highly expressed in the nuclei compared with HCN1 (Ludwig et al., 1998; Monteggia et al., 2000; Santoro et al., 2000; Chen et al., 2005), whereas immunohistochemistry suggests the presence of protein for all three subunits (Notomi & Shigemoto, 2004).
Gene_expression (expressed) of HCN1 associated with hcn1 and hcn2
19) Confidence 0.34 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0.16
Hyperpolarization-activated cyclic nucleotide-gated cation channel proteins (HCN1-4), which are potentially able to modulate membrane excitability, are abundantly expressed by neurons in spinal dorsal root ganglia (DRG).
Gene_expression (expressed) of HCN1-4 in neurons associated with hcn1
20) Confidence 0.29 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15016091 Disease Relevance 0.07 Pain Relevance 0.36

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