INT108724

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 8.12
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Thpo) extracellular space (Thpo) extracellular region (Thpo)
Anatomy Link Frequency
platelet 12
leukocyte 2
Thpo (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 7 99.20 Very High Very High Very High
Inflammation 26 98.92 Very High Very High Very High
Paracetamol 4 98.92 Very High Very High Very High
cytokine 9 93.80 High High
rheumatoid arthritis 16 92.28 High High
palliative 2 90.52 High High
fibrosis 5 87.84 High High
agonist 9 71.76 Quite High
Adalimumab 6 68.36 Quite High
Etanercept 10 67.88 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 1 99.84 Very High Very High Very High
Thrombocytopenia 65 99.78 Very High Very High Very High
Myelofibrosis 15 99.76 Very High Very High Very High
Nicotine Addiction 12 99.76 Very High Very High Very High
Inflammatory Bowel Disease 10 99.20 Very High Very High Very High
Cv General 3 Under Development 8 99.20 Very High Very High Very High
Thrombosis Related Under Development 45 99.16 Very High Very High Very High
Targeted Disruption 22 98.68 Very High Very High Very High
Acute Liver Failure 8 98.24 Very High Very High Very High
Purpura 4 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test its effect, we used the lethal murine model of myelofibrosis induced by thrombopoietin (TPO) overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of thrombopoietin associated with myelofibrosis
1) Confidence 0.70 Published 2007 Journal Blood Section Abstract Doc Link 17374740 Disease Relevance 1.07 Pain Relevance 0.25
In patients with active inflammatory bowel disease, Heits et al. [20], disclosed that the levels of thrombopoietin (TPO), which is the main regulator hormone of platelet production, were significantly increased in association with thrombocytosis and elevated IL-6 levels.
Positive_regulation (increased) of Gene_expression (levels) of thrombopoietin in platelet associated with inflammation and thrombosis related under development
2) Confidence 0.56 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2860341 Disease Relevance 1.08 Pain Relevance 0.31
To test its effect, we used the lethal murine model of myelofibrosis induced by thrombopoietin (TPO) overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TPO associated with myelofibrosis
3) Confidence 0.50 Published 2007 Journal Blood Section Abstract Doc Link 17374740 Disease Relevance 1.06 Pain Relevance 0.25
Despite severe hepatic dysfunction, serum TPO levels were initially normal and increased during hospitalization in acetaminophen-induced ALF, but did not prevent the development of thrombocytopenia.
Positive_regulation (increased) of Gene_expression (levels) of TPO associated with paracetamol, thrombocytopenia, acute liver failure and hepatotoxicity
4) Confidence 0.50 Published 2003 Journal Hepatology Section Abstract Doc Link 12601353 Disease Relevance 0.96 Pain Relevance 0.31
Results: Chronic cigarette smokers had higher circulating TPO levels than nonsmoking controls, as well as increased platelet-leukocyte binding, P-selectin expression, and CRP levels.
Positive_regulation (circulating) of Gene_expression (levels) of TPO in leukocyte associated with nicotine addiction
5) Confidence 0.47 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 20006331 Disease Relevance 0.88 Pain Relevance 0.11
Surprisingly, considering the often extremely low platelet counts in ITP patients, TPO levels are only minimally and thus inadequately elevated.19,25 Similar to ITP in other disorders with platelet destruction such as thrombotic-thrombocytopenic purpura or hemolytic-uremic syndrome, TPO levels in these patients are also only moderately increased.26,27 Considering these principles, stimulation of megakaryopoiesis has been recognized to be a potentially effective treatment strategy to increase platelet counts in patients with chronic ITP.


Positive_regulation (elevated.19,25) of Gene_expression (levels) of TPO in platelet associated with purpura, syndrome, thrombocytopenia and uremia
6) Confidence 0.46 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880346 Disease Relevance 1.14 Pain Relevance 0
OBJECTIVES: We sought to investigate the potential role of elevated levels of thrombopoietin (TPO) in platelet activation during unstable angina (UA).
Spec (investigate) Positive_regulation (elevated) of Gene_expression (levels) of TPO in platelet associated with angina
7) Confidence 0.44 Published 2006 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 17161245 Disease Relevance 0.17 Pain Relevance 0.17
OBJECTIVES: We sought to investigate the potential role of elevated levels of thrombopoietin (TPO) in platelet activation during unstable angina (UA).
Spec (investigate) Positive_regulation (elevated) of Gene_expression (levels) of thrombopoietin in platelet associated with angina
8) Confidence 0.44 Published 2006 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 17161245 Disease Relevance 0.17 Pain Relevance 0.17
RESULTS: Patients with UA showed higher circulating TPO levels, as well as increased monocyte-platelet binding, platelet P-selectin expression, and CRP levels, than those with SA and healthy control subjects.
Positive_regulation (circulating) of Gene_expression (levels) of TPO in platelet
9) Confidence 0.44 Published 2006 Journal J. Am. Coll. Cardiol. Section Body Doc Link 17161245 Disease Relevance 0.07 Pain Relevance 0
In patients with active inflammatory bowel disease, Heits et al. [20], disclosed that the levels of thrombopoietin (TPO), which is the main regulator hormone of platelet production, were significantly increased in association with thrombocytosis and elevated IL-6 levels.
Positive_regulation (increased) of Gene_expression (levels) of TPO in platelet associated with inflammation and thrombosis related under development
10) Confidence 0.40 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2860341 Disease Relevance 1.08 Pain Relevance 0.31
We observed serum hEPO (5.4 ± 1.6 ng/ml, n = 18) and mTPO (36 ± 20 ng/ml, n = 12) protein levels in the chimaeras (8 weeks of age, Figure 4B) that were elevated compared with those observed in transgenic animals described previously [hEPO: 0.1–0.15 ng/ml (6), human TPO: ?
Positive_regulation (elevated) of Gene_expression (levels) of mTPO associated with targeted disruption
11) Confidence 0.09 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1140086 Disease Relevance 0.43 Pain Relevance 0

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