INT108982

Context Info Confidence 0.51 First Reported 2003 Last Reported 2008 Negated 4 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 1.64 Pain Relevance 2.07

isomerase activity (Ptgds) transport (Ptgds) nuclear envelope (Ptgds) extracellular space (Ptgds) extracellular region (Ptgds) Golgi apparatus (Ptgds)

Anatomy Link Frequency spinal cord 4 dorsal root ganglia 4 Ptgds (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal cord 47 100.00 COX2 6 99.76 dexamethasone 4 98.80 Pain 39 96.72 Inflammation 42 96.48 cytokine 2 89.68 Neuropathic pain 1 82.48 Eae 4 78.28 cINOD 6 54.40 Hyperalgesia 23 51.40

Disease Link Frequency Relevance Heat Injury 5 97.40 Pain 58 96.72 INFLAMMATION 51 96.48 Frailty 3 86.60 Nervous System Injury 2 85.24 Neuropathic Pain 2 82.48 Inflammatory Pain 3 78.28 Necrosis 1 75.92 Cancer 1 75.56 Hyperalgesia 27 51.40

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Dexamethasone (1 mg/kg s.c. at -18 h and -1 h) attenuated the effect endotoxin on the expression of interleukin-1beta, cyclooxygenase-2, and membrane bound prostaglandin E synthase messenger RNA in all tissues investigated, but did not significantly influence expression of lipocalin prostaglandin D synthase mRNA in spinal cord and dorsal root ganglia.

Neg (not) Regulation (influence) of Gene_expression (expression) of lipocalin prostaglandin D synthase mRNA in dorsal root ganglia associated with dexamethasone and spinal cord

1) Confidence 0.51 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0 Pain Relevance 0.30

In contrast, basal expression of lipocalin prostaglandin D synthase messenger RNA in spinal cord and dorsal root ganglia was not significantly altered by endotoxin.

Neg (not) Regulation (altered) of Gene_expression (expression) of lipocalin prostaglandin D synthase in spinal cord associated with spinal cord

2) Confidence 0.22 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0.06 Pain Relevance 0.35

Dexamethasone (1 mg/kg s.c. at -18 h and -1 h) attenuated the effect endotoxin on the expression of interleukin-1beta, cyclooxygenase-2, and membrane bound prostaglandin E synthase messenger RNA in all tissues investigated, but did not significantly influence expression of lipocalin prostaglandin D synthase mRNA in spinal cord and dorsal root ganglia.

Neg (not) Regulation (influence) of in spinal cord Gene_expression (expression) of lipocalin prostaglandin D synthase mRNA in dorsal root ganglia associated with dexamethasone and spinal cord

3) Confidence 0.17 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0 Pain Relevance 0.30

COX-2-mediated PGD2 synthesis regulates phosphatidylcholine biosynthesis in rat renal papillary tissue.

Regulation (regulates) of Gene_expression (synthesis) of PGD2 associated with cox2

4) Confidence 0.16 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 14698037 Disease Relevance 0 Pain Relevance 0.05

We observed significant changes in expression of several key enzymes (3-alpha-hydroxysteroid dehydrogenase, phospholipase a2, prostaglandin d2 synthase, and COX2) involved in eicosanoid biosynthesis (Table 4, Arachidonic acid cascade and mediators of inflammation).

Regulation (changes) of Gene_expression (expression) of d2 synthase associated with inflammation and cox2

5) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 1.52 Pain Relevance 0.73

In contrast, basal expression of lipocalin prostaglandin D synthase messenger RNA in spinal cord and dorsal root ganglia was not significantly altered by endotoxin.

Neg (not) Regulation (altered) of in dorsal root ganglia Gene_expression (expression) of lipocalin prostaglandin D synthase in spinal cord associated with spinal cord

6) Confidence 0.08 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0.06 Pain Relevance 0.35

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