INT109034

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2011
Negated 2
Speculated 1
Reported most in Abstract
Documents 37
Total Number 38
Disease Relevance 17.11
Pain Relevance 14.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Eif2ak3) translation (Eif2ak3) kinase activity (Eif2ak3)
cell (Eif2ak3) response to stress (Eif2ak3) cytoplasm (Eif2ak3)
Anatomy Link Frequency
neurons 4
acinar cells 3
dorsal horn 2
hippocampus 2
hypothalamus 2
Eif2ak3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 100 100.00 Very High Very High Very High
Dorsal horn neuron 30 99.88 Very High Very High Very High
endometriosis 108 99.84 Very High Very High Very High
antagonist 199 99.76 Very High Very High Very High
withdrawal 252 99.72 Very High Very High Very High
dorsal root ganglion 167 99.68 Very High Very High Very High
Locus ceruleus 25 99.68 Very High Very High Very High
Hippocampus 14 99.68 Very High Very High Very High
nMDA receptor 78 99.56 Very High Very High Very High
Morphine 33 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Endometriosis 138 99.84 Very High Very High Very High
Ganglion Cysts 224 99.68 Very High Very High Very High
Stress 258 99.56 Very High Very High Very High
Injury 33 99.42 Very High Very High Very High
Nociception 202 99.28 Very High Very High Very High
Nervous System Injury 207 99.04 Very High Very High Very High
Pain 106 99.02 Very High Very High Very High
Hyperalgesia 77 98.80 Very High Very High Very High
Cancer 15 98.28 Very High Very High Very High
Diabetes Mellitus 83 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, expression of a Perk transgene in ?
Gene_expression (expression) of Perk
1) Confidence 0.77 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 1.16 Pain Relevance 0.04
The remarkable consistency in mutant pancreatic phenotype among all of the lines that are ablated for Perk in the exocrine pancreas is a strong indication that expression of PERK in acinar cells is required for their viability.
Gene_expression (expression) of PERK in acinar cells
2) Confidence 0.77 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.88 Pain Relevance 0.07
We also investigated the effect of morphine and beta-endorphin on pERK and pCaMK-IIalpha expression in the locus coeruleus (LC).
Gene_expression (expression) of pERK in locus coeruleus associated with locus ceruleus and morphine
3) Confidence 0.69 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18359081 Disease Relevance 0.07 Pain Relevance 0.79
The differential effect of morphine and beta-endorphin administered intracerebroventricularly on pERK and pCaMK-II expression induced by various nociceptive stimuli in mice brains.
Gene_expression (expression) of pERK in brains associated with nociception, pain and morphine
4) Confidence 0.69 Published 2008 Journal Neuropeptides Section Title Doc Link 18359081 Disease Relevance 0.10 Pain Relevance 0.64
For developmental stage-specific deletion of the Perk gene, tamoxifen (SIGMA) solution (20 mg/ml in corn oil) was injected (i.p.) into the Elastase-CreERT2 mice (2–3 months old) at 100 ?
Gene_expression (deletion) of Perk in developmental stage
5) Confidence 0.67 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.57 Pain Relevance 0
Central nervous system (CNS) activity evoked by acute administration of KA or exposure to a nociceptive stimulus was also determined by the immunocytochemical detection of Fos and of phosphorylated extracellular signal-regulated protein kinases 1 and 2 (pErk).
Spec (determined) Gene_expression (detection) of pErk in CNS associated with nociception and central nervous system
6) Confidence 0.60 Published 2003 Journal Pain Section Abstract Doc Link 12620595 Disease Relevance 0.99 Pain Relevance 1.07
The generation of the exocrine pancreas-specific Perk-knockout mice enabled us to critically test whether exocrine pancreas defects seen in the global PKO mouse are the direct result of the loss of PERK expression in the acinar cells or are secondary to defects occurring earlier in other tissues or organs.
Gene_expression (expression) of PERK in exocrine pancreas associated with targeted disruption
7) Confidence 0.60 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.68 Pain Relevance 0.07
Originally, luminal ER distention in PERK-deficient acinar cells was claimed as prime evidence for severe abnormality in protein folding in the ER, leading to cell death in the mutant exocrine pancreas [1,2].
Gene_expression (deficient) of PERK in acinar cells associated with death
8) Confidence 0.60 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.54 Pain Relevance 0
We show that expression of PERK in the acinar cells is required to maintain their viability but is not required for normal protein synthesis and secretion.
Gene_expression (expression) of PERK in acinar cells
9) Confidence 0.60 Published 2007 Journal BMC Cell Biol Section Abstract Doc Link PMC2072952 Disease Relevance 0.88 Pain Relevance 0.03
In addition, beta-endorphin significantly attenuated pERK expression induced by SP i.t. injection.
Gene_expression (expression) of pERK
10) Confidence 0.60 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18359081 Disease Relevance 0.07 Pain Relevance 0.79
In the immunoblot assay, the increases of phosphorylated extracellular signal-regulated protein kinase (pERK) as well as phosphorylated calcium/calmodulin-dependent protein kinase IIalpha (pCaMK-IIalpha) expression induced by noxious stimuli were attenuated by intracerebroventricular (i.c.v.) beta-endorphin pretreatment in the hypothalamus, but not by i.c.v. morphine pretreatment.
Gene_expression (expression) of pERK in hypothalamus associated with intracerebroventricular and morphine
11) Confidence 0.60 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18359081 Disease Relevance 0.07 Pain Relevance 0.48
I.c.v. injection of morphine significantly increased pERK as well as pCaMK-IIalpha expression in the locus coeruleus, while beta-endorphin increased only pCaMK-IIalpha in the LC.
Gene_expression (expression) of pERK in locus coeruleus associated with locus ceruleus and morphine
12) Confidence 0.60 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18359081 Disease Relevance 0.07 Pain Relevance 0.80
In the current study, we report elevated levels of p-ERK in endometriosis, suggesting activation of the MAPK pathway.
Gene_expression (levels) of p-ERK associated with endometriosis
13) Confidence 0.58 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.00 Pain Relevance 0.32
In an immunoblot study, s.c. injection of formalin and intrathecal (i.t.) injections of glutamate, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1 beta) significantly increased pCaMKIIalpha expression in the hippocampus, but i.p. injections of acetic acid did not. pERK1/2 expression was also increased by i.t. injection of glutamate, TNF-alpha, and IL-1beta but not by s.c. injections of formalin or i.p. injections of acetic acid.
Gene_expression (expression) of pERK in hippocampus associated with necrosis, glutamate, cancer, hippocampus and intrathecal
14) Confidence 0.58 Published 2008 Journal Neuroscience Section Abstract Doc Link 18771711 Disease Relevance 0.48 Pain Relevance 0.40
Furthermore, in formalin inflammation pain model, pre-inhibition of EphBs receptors by the injection of EphB1-Fc reduces pain behavior, which is accompanied by the decreased expression of peripheral p-p38, pERK and pJNK.
Gene_expression (expression) of pERK associated with pain and inflammation
15) Confidence 0.57 Published 2008 Journal Pain Section Abstract Doc Link 18706764 Disease Relevance 0.59 Pain Relevance 0.72
At the supraspinal level, although pERK was not changed in the hippocampus induced by formalin s.c. injection, pCaMK-IIalpha was increased in the hippocampus and hypothalamus by s.c. formalin injection, and an increase of pCaMK-IIalpha immunoreactivity mainly occurred in the pyramidal cells and the stratum lucidum/radiatum layer of the CA3 region of hippocampus and paraventricular nucleus of the hypothalamus.
Neg (not) Gene_expression (changed) of pERK in hypothalamus associated with pyramidal cell and hippocampus
16) Confidence 0.56 Published 2006 Journal Brain Res. Section Abstract Doc Link 16863646 Disease Relevance 0.31 Pain Relevance 0.44
None of these antagonist treatments produced specific pERK signals.
Gene_expression (produced) of pERK associated with antagonist
17) Confidence 0.53 Published 2008 Journal Mol Pain Section Body Doc Link PMC2488330 Disease Relevance 0 Pain Relevance 0.31
Interestingly, we previously found that the pERK expression was specific for nociceptive C-fiber- and A?
Gene_expression (expression) of pERK associated with nociception and c fibre
18) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2599895 Disease Relevance 0.31 Pain Relevance 0.32
As the noxious stimulation rapidly activates ERK in superficial dorsal horn neurons, the pERK expression could be used as a biochemical marker of activated neurons [6].
Gene_expression (expression) of pERK in neurons associated with dorsal horn neuron
19) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2599895 Disease Relevance 0.32 Pain Relevance 0.35
In the present study, we characterized differential expressions of phosphorylated Ca(2+)/calmodulin-dependent protein kinase IIalpha (pCaMKIIalpha) and phosphorylated extracellular signal-regulated protein (pERK) in the mouse hippocampus induced by various nociceptive stimuli.
Gene_expression (expressions) of pERK in hippocampus associated with nociception and hippocampus
20) Confidence 0.46 Published 2008 Journal Neuroscience Section Abstract Doc Link 18771711 Disease Relevance 0.35 Pain Relevance 0.25

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