INT109219

Context Info Confidence 0.43 First Reported 2003 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 1.22 Pain Relevance 4.25

plasma membrane (Cdk5r1) nucleus (Cdk5r1) embryo development (Cdk5r1) cell cycle (Cdk5r1) kinase activity (Cdk5r1) cytoplasm (Cdk5r1)

Anatomy Link Frequency brain 2 neuronal 1 neurons 1 cortex 1 Cdk5r1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dorsal horn neuron 6 100.00 Inflammation 2 100.00 Opioid 20 99.84 addiction 12 99.60 opiate 12 99.40 Morphine 8 99.16 Hyperalgesia 3 99.04 Pain 1 98.60 cerebral cortex 4 97.08 allodynia 1 93.72

Disease Link Frequency Relevance Heat INFLAMMATION 2 100.00 Nociception 1 100.00 Opiate Addiction 12 99.60 Hyperalgesia 3 99.04 Pain 1 98.60 Neuropathic Pain 1 93.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, chronic morphine (10-100 mg/kg for 5 days) induced marked decreases in cdk5 (40%) and p35 (47%) in rat brain.

Negative_regulation (decreases) of p35 in brain associated with morphine

1) Confidence 0.43 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.15 Pain Relevance 0.95

Downregulation of neuronal cdk5/p35 in opioid addicts and opiate-treated rats: relation to neurofilament phosphorylation.

Negative_regulation (Downregulation) of p35 in neuronal associated with opiate and opioid

2) Confidence 0.32 Published 2003 Journal Neuropsychopharmacology Section Title Doc Link 12637947 Disease Relevance 0.09 Pain Relevance 0.71

The results suggest that opiate addiction is associated with downregulation of cdk5/p35 levels in the brain.

Negative_regulation (downregulation) of p35 in brain associated with addiction and opiate

3) Confidence 0.32 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.15 Pain Relevance 0.93

Decreased immunodensities of cdk5 (18%) and p35 (26-44%) were found in the prefrontal cortex of opioid addicts compared with matched controls.

Negative_regulation (Decreased) of p35 in cortex associated with opioid

4) Confidence 0.31 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.09 Pain Relevance 0.73

We conclude that Cdk5/p35 and Cdk5/p25 complexes in primary sensory and dorsal horn neurons may potentially be involved in nociceptive transmission after inflammation and may be employed in synaptic plasticity underlying pain hypersensitization.

Negative_regulation (employed) of p35 in neurons associated with nociception, pain, inflammation and dorsal horn neuron

5) Confidence 0.14 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.73 Pain Relevance 0.92

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