INT109223

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 3.27
Pain Relevance 12.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
neurons 2
brain 2
neuronal 1
nerve 1
cortex 1
Cdk5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 18 100.00 Very High Very High Very High
Inflammation 6 100.00 Very High Very High Very High
intrathecal 12 99.98 Very High Very High Very High
Morphine 43 99.84 Very High Very High Very High
Opioid 20 99.68 Very High Very High Very High
addiction 12 99.60 Very High Very High Very High
opiate 12 99.40 Very High Very High Very High
Hyperalgesia 9 99.24 Very High Very High Very High
analgesia 2 99.16 Very High Very High Very High
Spinal cord 13 98.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 100.00 Very High Very High Very High
Nociception 3 100.00 Very High Very High Very High
Opiate Addiction 12 99.60 Very High Very High Very High
Poisoning 3 99.58 Very High Very High Very High
Hyperalgesia 9 99.24 Very High Very High Very High
Pain 5 98.60 Very High Very High Very High
Neuropathic Pain 12 94.92 High High
Newborn Drug Withdrawal Syndrome 1 85.68 High High
Peripheral Neuropathy 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine, in contrast, induced a decrease in Cdk5 activity which was also maximal on day 14.
Negative_regulation (decrease) of Cdk5 associated with morphine
1) Confidence 0.59 Published 2006 Journal Neurotoxicol Teratol Section Abstract Doc Link 16962740 Disease Relevance 0.09 Pain Relevance 0.43
Although increases of CDK5 contents in both the cytosolic and membrane fractions of SC in 200 and 400mg/kg HD-treated rats were also observed, CDK5 activities were significantly decreased in the cytosolic fraction and negatively correlated with gait abnormality.
Negative_regulation (decreased) of CDK5 associated with spinal cord
2) Confidence 0.58 Published 2008 Journal Toxicology Section Abstract Doc Link 18423835 Disease Relevance 0.29 Pain Relevance 0.44
Intrathecal pretreatment with Roscovitine, a specific inhibitor of Cdk5 activity, and intrathecal delivery of the DN-Cdk5(N144) gene both alleviated CFA-induced heat hyperalgesia but not mechanical allodynia.
Negative_regulation (inhibitor) of Cdk5 associated with hyperalgesia, allodynia and intrathecal
3) Confidence 0.57 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.42 Pain Relevance 0.87
Downregulation of neuronal cdk5/p35 in opioid addicts and opiate-treated rats: relation to neurofilament phosphorylation.
Negative_regulation (Downregulation) of cdk5 in neuronal associated with opiate and opioid
4) Confidence 0.49 Published 2003 Journal Neuropsychopharmacology Section Title Doc Link 12637947 Disease Relevance 0.09 Pain Relevance 0.71
In contrast, chronic morphine (10-100 mg/kg for 5 days) induced marked decreases in cdk5 (40%) and p35 (47%) in rat brain.
Negative_regulation (decreases) of cdk5 in brain associated with morphine
5) Confidence 0.49 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.14 Pain Relevance 0.95
The results suggest that opiate addiction is associated with downregulation of cdk5/p35 levels in the brain.
Negative_regulation (downregulation) of cdk5 in brain associated with addiction and opiate
6) Confidence 0.49 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.15 Pain Relevance 0.93
Intrathecal cdk5 inhibitor, roscovitine, attenuates morphine antinociceptive tolerance in rats.
Negative_regulation (inhibitor) of cdk5 associated with tolerance, antinociceptive, morphine and intrathecal
7) Confidence 0.43 Published 2004 Journal Acta Pharmacol. Sin. Section Title Doc Link 15301735 Disease Relevance 0 Pain Relevance 0.43
Thus, HD intoxication was associated with deregulation of CDK5 and its activator p35 or p25 in nerve tissues.
Negative_regulation (deregulation) of CDK5 in nerve associated with poisoning
8) Confidence 0.43 Published 2008 Journal Toxicology Section Abstract Doc Link 18423835 Disease Relevance 0.28 Pain Relevance 0.42
The results showed that the levels and activities of CDK5 in CC of 200 or 400mg/kg HD-treated rats were significantly decreased in both the cytosolic and membrane fractions and negatively correlated with gait abnormality in the cytosolic fraction.
Negative_regulation (decreased) of CDK5
9) Confidence 0.43 Published 2008 Journal Toxicology Section Abstract Doc Link 18423835 Disease Relevance 0.25 Pain Relevance 0.35
Effects of glycogen synthase kinase 3beta and cyclin-dependent kinase 5 inhibitors on morphine-induced analgesia and tolerance in rats.
Negative_regulation (inhibitors) of cyclin-dependent kinase 5 associated with tolerance, analgesia and morphine
10) Confidence 0.42 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16902054 Disease Relevance 0 Pain Relevance 1.45
We conclude that Cdk5/p35 and Cdk5/p25 complexes in primary sensory and dorsal horn neurons may potentially be involved in nociceptive transmission after inflammation and may be employed in synaptic plasticity underlying pain hypersensitization.
Negative_regulation (employed) of Cdk5 in neurons associated with nociception, pain, inflammation and dorsal horn neuron
11) Confidence 0.42 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.73 Pain Relevance 0.92
We conclude that Cdk5/p35 and Cdk5/p25 complexes in primary sensory and dorsal horn neurons may potentially be involved in nociceptive transmission after inflammation and may be employed in synaptic plasticity underlying pain hypersensitization.
Negative_regulation (employed) of Cdk5 in neurons associated with nociception, pain, inflammation and dorsal horn neuron
12) Confidence 0.42 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.73 Pain Relevance 0.92
Our studies indicated that inhibition of Cdk5 activity or overexpression of a DOR mutant lacking the Cdk5 phosphorylation site displayed relatively low cell surface expression and relatively low abilities to form heterodimers of DOR and MOR; intrathecal delivery of a construct expressing the T161A mutant of DOR attenuated morphine antinociceptive tolerance in rats, suggesting that Thr-161 phosphorylation of DOR contributed to Cdk5-mediated morphine antinociceptive tolerance.
Negative_regulation (inhibition) of Cdk5 associated with tolerance, opioid receptor, antinociceptive, morphine and intrathecal
13) Confidence 0.40 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295160 Disease Relevance 0 Pain Relevance 1.81
Disruption of Cdk5-associated phosphorylation of residue threonine-161 of the delta-opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance.
Negative_regulation (Disruption) of Cdk5 associated with tolerance, opioid receptor, antinociceptive and morphine
14) Confidence 0.40 Published 2009 Journal J. Neurosci. Section Title Doc Link 19295160 Disease Relevance 0 Pain Relevance 1.37
Decreased immunodensities of cdk5 (18%) and p35 (26-44%) were found in the prefrontal cortex of opioid addicts compared with matched controls.
Negative_regulation (Decreased) of cdk5 in cortex associated with opioid
15) Confidence 0.36 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.09 Pain Relevance 0.72

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