INT10929

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Context Info
Confidence 0.67
First Reported 1992
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 46
Total Number 47
Disease Relevance 13.17
Pain Relevance 24.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (FLII) cytoskeleton (FLII) nucleus (FLII)
cytoplasm (FLII)
Anatomy Link Frequency
nucleus 6
neurons 3
MRF 2
CEA 2
dorsal 2
FLII (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 21 99.98 Very High Very High Very High
Ventral tegmentum 8 99.84 Very High Very High Very High
amygdala 32 99.72 Very High Very High Very High
electroacupuncture 22 99.70 Very High Very High Very High
nMDA receptor 4 99.68 Very High Very High Very High
Locus ceruleus 18 99.64 Very High Very High Very High
Dorsal horn 11 99.64 Very High Very High Very High
antagonist 23 99.54 Very High Very High Very High
Nicotine 19 99.50 Very High Very High Very High
Eae 33 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 15 99.98 Very High Very High Very High
Aids-related Complex 12 99.72 Very High Very High Very High
Appetite Loss 3 99.58 Very High Very High Very High
Injury 33 99.48 Very High Very High Very High
Urological Neuroanatomy 22 97.28 Very High Very High Very High
Vomiting 24 96.44 Very High Very High Very High
Eating Disorder 18 96.44 Very High Very High Very High
Hyperalgesia 11 96.32 Very High Very High Very High
Pain 21 94.72 High High
Nociception 43 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(vi) The induction of FLI was related to noxious stimulation intensity.
Positive_regulation (induction) of FLI
1) Confidence 0.67 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8930788 Disease Relevance 0.19 Pain Relevance 0.12
(v) This increase in FLI was expressed bilaterally and restricted largely to the intermediate white layer.
Positive_regulation (increase) of FLI
2) Confidence 0.59 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8930788 Disease Relevance 0.20 Pain Relevance 0.06
The meal-paired environment increased FLI in the VTA and nucleus accumbens shell (NAC shell).
Positive_regulation (increased) of FLI in shell associated with nucleus accumbens and ventral tegmentum
3) Confidence 0.40 Published 1998 Journal Brain Res. Section Abstract Doc Link 9733960 Disease Relevance 0.10 Pain Relevance 0.43
(ix) There were no differences in the distribution of FLI induced by noxious mechanical or noxious chemical stimulation.
Positive_regulation (induced) of FLI
4) Confidence 0.39 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8930788 Disease Relevance 0.22 Pain Relevance 0.24
(iv) Unilateral noxious mechanical stimulation elicited a reliable increase in FLI over all control conditions.
Positive_regulation (increase) of FLI
5) Confidence 0.39 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8930788 Disease Relevance 0.21 Pain Relevance 0.04
(x) The increase in FLI induced by noxious pinch was abolished by a naloxone reversible pre-treatment with morphine.
Positive_regulation (induced) of FLI associated with narcan and morphine
6) Confidence 0.39 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8930788 Disease Relevance 0.24 Pain Relevance 0.24
(ii) Urethane anaesthesia induced an increase in Fos-like immunoreactivity (FLI) over the basal condition.
Positive_regulation (increase) of FLI
7) Confidence 0.39 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8930788 Disease Relevance 0.22 Pain Relevance 0.04
(x) The increase in FLI induced by noxious pinch was abolished by a naloxone reversible pre-treatment with morphine.
Positive_regulation (increase) of FLI associated with narcan and morphine
8) Confidence 0.39 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8930788 Disease Relevance 0.24 Pain Relevance 0.24
The aim of this study was to investigate whether intraplantar (i.pl.) injections of endotoxin (ET, 1.25 microg) can induce FLI in the lumbar spinal cord of rats and to assess the effects of morphine injection on c-fos expression.
Positive_regulation (induce) of FLI in spinal cord associated with morphine and spinal cord
9) Confidence 0.38 Published 1997 Journal Brain Res. Section Abstract Doc Link 9374273 Disease Relevance 0.19 Pain Relevance 0.36
We conclude that local injections of ET can induce FLI in the lumbar spinal cord with a temporal and spatial patterns comparable to the described hyperalgesia, and that both FLI and hyperalgesia are reduced by morphine in a dose-dependent manner with a maximal effect shown by the local i.pl. morphine injections.
Positive_regulation (induce) of FLI in spinal cord associated with hyperalgesia, morphine and spinal cord
10) Confidence 0.38 Published 1997 Journal Brain Res. Section Abstract Doc Link 9374273 Disease Relevance 0.34 Pain Relevance 0.82
Following nicotine and capsaicin, there was a significant increase in fos-like immunoreactivity (FLI) compared with controls in the following areas: nucleus of the solitary tract from the level of the pyramidal decussation caudally to the level of the area postrema rostrally; dorsomedial aspect of trigeminal subnucleus caudalis (Vc); and paratrigeminal islands interspersed in the spinal trigeminal tract.
Positive_regulation (increase) of FLI in spinal associated with qutenza and nicotine
11) Confidence 0.38 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12520409 Disease Relevance 0 Pain Relevance 0.42
In addition, there was a significant increase in FLI in area postrema and the ventrolateral medullary region dorsal to the lateral reticular nucleus following nicotine but not capsaicin.
Positive_regulation (increase) of FLI in lateral reticular nucleus associated with qutenza and nicotine
12) Confidence 0.38 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12520409 Disease Relevance 0 Pain Relevance 0.51
Multivariate analysis of variance revealed no significant difference in spatial distributions of FLI induced by any of the chemical or pinch stimuli.
Positive_regulation (induced) of FLI
13) Confidence 0.32 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 12110967 Disease Relevance 0 Pain Relevance 0.55
Since naltrexone, alone, increased FLI in VTA, NAC shell, central amygdala (ceA) and laterodorsal bed nucleus of the stria terminalis (BSTLD), the blunting of ingestion reward by naltrexone may result from direct or transsynaptic activating effects on opponent neuronal activity within this highly interconnected set of structures that mediate and modulate reward.
Positive_regulation (increased) of FLI in neuronal associated with ventral tegmentum and amygdala
14) Confidence 0.24 Published 1998 Journal Brain Res. Section Abstract Doc Link 9733960 Disease Relevance 0.09 Pain Relevance 0.33
CP55,940 suppressed pain behavior and FLI induced by intraplantar formalin.
Positive_regulation (induced) of FLI
15) Confidence 0.21 Published 1999 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 11216448 Disease Relevance 0 Pain Relevance 0
Electrical stimulation of the PBN (10 sec on, 10 sec off; 15-50 microA at 20 Hz for 60-90 min) in rats anesthetized with urethane led to increases in mean arterial pressure (10-30 mm Hg) and to ipsilateral increases of FLI in the lateral PBN, dorsal division of SON, ACE, endopiriform nucleus, insular cortex, piriform cortex, and islands of Calleja.
Positive_regulation (increases) of FLI in insular cortex associated with amygdala
16) Confidence 0.14 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1527597 Disease Relevance 0.17 Pain Relevance 0.43
Ketanserin (5 mug) markedly reduced carrageenan-induced FLI in all laminae of the dorsal horn.
Positive_regulation (induced) of FLI in dorsal horn associated with dorsal horn
17) Confidence 0.11 Published 2005 Journal Neuroscience Section Abstract Doc Link 15857711 Disease Relevance 0.71 Pain Relevance 0.78
Following application of nicotine, there were significant increases in FLI compared with saline-treated controls in dorsomedial and ventrolateral aspects of the trigeminal caudalis.
Positive_regulation (increases) of FLI associated with nicotine
18) Confidence 0.06 Published 2000 Journal Exp Brain Res Section Abstract Doc Link 10883386 Disease Relevance 0.06 Pain Relevance 0.57
The CCK-A receptor antagonist MK-329 (0.1 mg/kg i.p.) diminished the FLI increase in LC, NTS, AP, and PVN by 39-100%; the CCK-B receptor antagonist L-365,260 reduced the increased FLI in the AP by 54%.
Positive_regulation (increased) of FLI in PVN associated with antagonist and cholecystokinin
19) Confidence 0.06 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435662 Disease Relevance 0 Pain Relevance 0.77
This study indicates that NMDA receptor is involved in upregulating FLI in response to non-noxious stimulation of CCI rats.
Positive_regulation (upregulating) of FLI associated with eae and nmda receptor
20) Confidence 0.06 Published 2001 Journal Brain Res. Section Abstract Doc Link 11489249 Disease Relevance 0.79 Pain Relevance 0.61

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