INT109305

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.69
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
Anatomy Link Frequency
neuronal 1
liver 1
granulosa cells 1
hearts 1
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 99.68 Very High Very High Very High
Inflammatory response 30 98.76 Very High Very High Very High
withdrawal 6 93.80 High High
opioid receptor 86 92.40 High High
Kinase C 57 90.40 High High
cytokine 89 89.88 High High
agonist 5 85.16 High High
antagonist 10 81.16 Quite High
narcan 2 79.88 Quite High
Inflammation 76 76.20 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 52 99.36 Very High Very High Very High
INFLAMMATION 106 98.40 Very High Very High Very High
Bordatella Infection 1 98.00 Very High Very High Very High
Shock 193 97.04 Very High Very High Very High
Stress 103 96.88 Very High Very High Very High
Hypoxia 59 96.24 Very High Very High Very High
Congenital Anomalies 7 93.44 High High
Disease 111 92.08 High High
Frailty 5 91.32 High High
Hypertrophy 42 85.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the membrane, PI3K phosphorylates PI(4,5)P2 at the D3 position on the inositol ring producing PI(3,4,5)P3 [16], an important second messenger required for the oncogenic [17] and growth factor [18] induced activation of mTORC1.
Phosphorylation (phosphorylates) of PI3K
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.17 Pain Relevance 0
As expected, MES promoted the tyrosine phosphorylation of YXXM motif in IRS protein (IRS-1 and IRS-2) (Fig. 8F; pYXXM) that leads to the activation of PI3K and Akt phosphorylation in the liver [37].
Phosphorylation (phosphorylation) of PI3K in liver
2) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.14 Pain Relevance 0
Protein phosphorylation pathways, including MAPK, PI3K, and PKC, have been implicated in the regulation of ARE response to chemical stress (Nguyen et al. 2003).
Phosphorylation (phosphorylation) of PI3K associated with stress
3) Confidence 0.49 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.21 Pain Relevance 0
Upon activation, PI3K phosphorylates phosphatidylinositol (4,5) bisphosphate (PI(4,5)P2) to PI(3,4,5)P3, which is the main lipid second messenger for downstream signaling.
Phosphorylation (phosphorylates) of PI3K
4) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994819 Disease Relevance 0.59 Pain Relevance 0.15
MES increased Akt phosphorylation through PI3K in HepG2 cells
Phosphorylation (phosphorylation) of PI3K
5) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.07 Pain Relevance 0.03
DAMGO also stimulated Akt phosphorylation via PI 3-K in this primary neuronal culture.
Phosphorylation (phosphorylation) of PI 3-K in neuronal
6) Confidence 0.37 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12646285 Disease Relevance 0.39 Pain Relevance 0.53
Ser473 phosphorylation is dependent on PI3K.
Phosphorylation (phosphorylation) of PI3K
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.46
Activated Akt phosphorylates several downstream targets of the PI3K signaling pathway such as GSK3?.
Phosphorylation (phosphorylates) of PI3K
8) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 0.96 Pain Relevance 0.20
can be activated through the inhibition of insulin/IGF1 signalling via the Wnt pathway, which is not dependent on PI3K/AKT phosphorylation.
Phosphorylation (phosphorylation) of PI3K
9) Confidence 0.20 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.06 Pain Relevance 0.06
Akt1 is a component of the phosphoinositide 3'-OH kinase (PI3K) pathway and is phosphorylated in response to Igf1 stimulation of bovine granulosa cells [38].
Phosphorylation (phosphorylated) of PI3K in granulosa cells
10) Confidence 0.19 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.14 Pain Relevance 0
Acetaminophen also increased phosphorylated PI-3K, but this was delayed 6-12 h in TNFR1-/- mice.
Phosphorylation (phosphorylated) of PI-3K associated with paracetamol
11) Confidence 0.15 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.54 Pain Relevance 0.85
Given the capacity of PI3K to phosphorylate AKT we characterized the composition of the lipid raft formed during the interaction of B. burgdorferi with CD14+/+ and CD14?
Phosphorylation (phosphorylate) of PI3K
12) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0.04
expression and activation can be promoted by non-hypoxic mechanisms likely to be active in hypertrophying hearts, including increased reactive oxygen species production, mechanical stretch-activated channels, and phosphatidylinositol 3-kinase (PI3-K)-dependent Akt phosphorylation [20].
Phosphorylation (phosphorylation) of PI3-K in hearts associated with hypoxia
13) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 0.41 Pain Relevance 0

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