INT109313

Context Info Confidence 0.48 First Reported 2003 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 1.78 Pain Relevance 1.98

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8) nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)

Mapk8 (Mus musculus)

Pain Link Frequency Relevance Heat Buprenorphine 1 99.66 Morphine 4 99.02 Opioid 5 98.82 tolerance 2 98.18 Analgesic 7 97.98 opioid receptor 5 91.16 methadone 1 90.96 Oxycodone 1 89.76 Kappa opioid receptor 2 84.60 Spinal cord 35 78.64

Disease Link Frequency Relevance Heat Sprains And Strains 57 99.20 Hepatocellular Cancer 47 98.72 Targeted Disruption 20 98.36 Liver Cancer 3 92.04 Cancer 41 83.64 Hepatitis C Virus Infection 8 80.76 Hepatitis B Virus Infection 8 80.44 Low Back Pain 1 65.96 INFLAMMATION 31 64.60 Pain 23 51.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Haplotypic analysis using the method of Wang et al. was conducted to determine the degree of association of the Mapk8 haplotype with the strain specific data [19].

Mapk8 Binding (association) of associated with sprains and strains

1) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.66 Pain Relevance 0.29

A second function of this protein in cell defense has recently been proposed that is related to its ability to interact with c-Jun N-terminal kinase (JNK).

c-Jun N-terminal kinase Binding (interact) of

2) Confidence 0.47 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12646564 Disease Relevance 0 Pain Relevance 0

A second function of this protein in cell defense has recently been proposed that is related to its ability to interact with c-Jun N-terminal kinase (JNK).

JNK Binding (interact) of

3) Confidence 0.47 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12646564 Disease Relevance 0 Pain Relevance 0

-deficient mice, and the results showed that JNK1 is a critical factor for the increased incidence of HCC in Ikk?

JNK1 Binding (factor) of associated with hepatocellular cancer

4) Confidence 0.34 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.94 Pain Relevance 0.06

Acute analgesic tolerance to morphine and related opioids (morphine-6-glucuronide and buprenorphine) was blocked by JNK inhibition, but not by G protein receptor kinase 3 knockout.

JNK Neg (inhibition) Binding (inhibition) of associated with targeted disruption, analgesic, tolerance, opioid, buprenorphine and morphine

5) Confidence 0.32 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20534436 Disease Relevance 0.18 Pain Relevance 1.62

, 3.3 for JNK1, 3.1 for JNK2, 3.1 for JNK3, 3.6 for c-jun, and 3.1 for ACTB), indicating that the cDNA was amplified with similar efficiency.

JNK1 Binding (indicating) of

6) Confidence 0.10 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 0 Pain Relevance 0

General Comments

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