INT109390

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 4.08
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
nucleolus (Flt1) plasma membrane (Flt1) nucleus (Flt1)
Anatomy Link Frequency
retina 4
inner nuclear layer 3
endothelial cell 2
TMJ 2
ganglion cell layer 1
Flt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 5 97.92 Very High Very High Very High
corticosteroid 28 94.16 High High
cINOD 1 87.80 High High
cytokine 8 18.80 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 220 100.00 Very High Very High Very High
Ganglion Cysts 8 99.12 Very High Very High Very High
Pancreatic Cancer 4 98.40 Very High Very High Very High
Temporomandibular Joint Syndrome 5 97.92 Very High Very High Very High
Papilledema 4 95.84 Very High Very High Very High
Cancer 46 94.96 High High
Colon Cancer 2 92.48 High High
Neuroblastoma 1 89.52 High High
INFLAMMATION 1 87.08 High High
Diabetic Macular Edema 84 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also show that IVTA does not alter physiological VEGF-A, FLK-1, and FLT-1 levels in the normal retina.
Neg (not) Regulation (alter) of Gene_expression (levels) of FLT-1 in retina
1) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.67 Pain Relevance 0.05
The expression of VEGF-A and its two receptors (FLK-1 and FLT-1) was found predominantly in the ganglion cell layer, inner nuclear layer, and outer plexiform layer of all four treatment groups.
Regulation (found) of Gene_expression (expression) of FLT-1 in inner nuclear layer associated with ganglion cysts
2) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.51 Pain Relevance 0
By contrast, Flt-1 expression was decreased in early diabetic retinas but was upregulated following IVTA treatment.
Regulation (upregulated) of Gene_expression (expression) of Flt-1 in retinas associated with diabetes mellitus
3) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.71 Pain Relevance 0
From the present study it may be suggested that the marked reduction in Flt1 and VEGF expression caused by GLA treatment could cause a reduction in angiogenesis as seen by reduced MVD most likely through reduced endothelial cell proliferation, although this was not quantified directly.
Regulation (caused) of Gene_expression (expression) of Flt1 in endothelial cell
4) Confidence 0.31 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.55 Pain Relevance 0
Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells.
Regulation (Regulation) of Gene_expression (expression) of vascular endothelial growth factor receptor-1 associated with pancreatic cancer
5) Confidence 0.23 Published 2007 Journal Cancer Res. Section Title Doc Link 17409437 Disease Relevance 0.71 Pain Relevance 0.09
The expression of VEGF-A and its two receptors (FLK-1 and FLT-1) was found predominantly in the ganglion cell layer, inner nuclear layer, and outer plexiform layer of all four treatment groups.
Regulation (found) of in ganglion cell layer Gene_expression (expression) of FLT-1 in inner nuclear layer associated with ganglion cysts
6) Confidence 0.14 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.51 Pain Relevance 0
These results suggest that the expression of the VEGF/Flt-1 system is involved in angiogenesis in inflamed synovial tissue in the TMJ.
Regulation (involved) of Gene_expression (expression) of Flt-1 in TMJ associated with snapping jaw
7) Confidence 0.07 Published 2003 Journal J. Dent. Res. Section Abstract Doc Link 12651930 Disease Relevance 0.43 Pain Relevance 0.37

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