INT109391

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Context Info
Confidence 0.56
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.78
Pain Relevance 3.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fgfr1) cytoplasmic membrane-bounded vesicle (Fgfr1) plasma membrane (Fgfr1)
nucleus (Fgfr1) cytoplasm (Fgfr1)
Anatomy Link Frequency
neurons 2
TMJ 2
sciatic nerve 1
fibroblast 1
astrocytes 1
Fgfr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 18 99.84 Very High Very High Very High
Substantia nigra 2 99.58 Very High Very High Very High
Morphine 12 99.40 Very High Very High Very High
Sciatic nerve 3 98.96 Very High Very High Very High
Dopamine 4 98.76 Very High Very High Very High
gABA 4 98.24 Very High Very High Very High
Snapping jaw 10 96.72 Very High Very High Very High
Peripheral nerve injury 1 96.24 Very High Very High Very High
chemokine 4 95.80 Very High Very High Very High
cytokine 7 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 10 96.72 Very High Very High Very High
Nervous System Injury 1 96.24 Very High Very High Very High
Ganglion Cysts 7 94.32 High High
Synovitis 2 87.60 High High
Drug Dependence 2 85.88 High High
Dysmenorrhea 2 81.84 Quite High
Injury 1 80.88 Quite High
Neuropathic Pain 2 75.00 Quite High
Pain 1 47.52 Quite Low
Neuritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ligation of the sciatic nerve down-regulated FGFR2, -3 and -4 mRNA; however, the expression of FGFR1 mRNA showed no change.
Gene_expression (expression) of FGFR1 in sciatic nerve associated with sciatic nerve
1) Confidence 0.56 Published 2007 Journal Neuroscience Section Abstract Doc Link 17905520 Disease Relevance 0.67 Pain Relevance 0.49
stimulated the expression of basic fibroblast growth receptor factor 1 (bFGRF1) (Table 4).


Gene_expression (expression) of basic fibroblast growth receptor factor 1 in fibroblast
2) Confidence 0.41 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0.08 Pain Relevance 0.28
This is shown in Figure 4 reporting the MFR (Figure 4A) and MBR (Figure 4B) calculated for 7 preparations on subsets of electrodes featuring an increasing electrode density.
Gene_expression (reporting) of MFR
3) Confidence 0.36 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2871691 Disease Relevance 0 Pain Relevance 0
In order to evaluate the spatial distribution of these highly active neurons, Figure 5D provides a representation in false color maps of sites with a MFR >0.5?
Gene_expression (>0.5) of MFR in neurons
4) Confidence 0.36 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2871691 Disease Relevance 0 Pain Relevance 0
The objective of this study was to elucidate the correlation between the expression of FGF-2, VEGF, and their receptors-FGF receptor-1 (FGFR-1) and VEGF receptor-1 (Flt-1)-with microvessel density in synovial tissues of the TMJ.
Gene_expression (expression) of FGFR-1 in TMJ associated with snapping jaw
5) Confidence 0.14 Published 2003 Journal J. Dent. Res. Section Abstract Doc Link 12651930 Disease Relevance 0.44 Pain Relevance 0.35
The objective of this study was to elucidate the correlation between the expression of FGF-2, VEGF, and their receptors-FGF receptor-1 (FGFR-1) and VEGF receptor-1 (Flt-1)-with microvessel density in synovial tissues of the TMJ.
Gene_expression (expression) of receptors-FGF receptor-1 in TMJ associated with snapping jaw
6) Confidence 0.12 Published 2003 Journal J. Dent. Res. Section Abstract Doc Link 12651930 Disease Relevance 0.44 Pain Relevance 0.35
Infusions into the adjacent substantia nigra, whose neurons also express FGF-1 and FGFR-1, did not modify normal morphine-induced sensitization.
Gene_expression (express) of FGFR-1 in neurons associated with substantia nigra and morphine
7) Confidence 0.05 Published 2010 Journal Neuroscience Section Abstract Doc Link 19819303 Disease Relevance 0.07 Pain Relevance 1.19
The receptor FGFR-1 is expressed on VTA astrocytes, as well as dopamine and GABA neurons.
Gene_expression (expressed) of FGFR-1 in astrocytes associated with ventral tegmentum, gaba and dopamine
8) Confidence 0.05 Published 2010 Journal Neuroscience Section Abstract Doc Link 19819303 Disease Relevance 0.09 Pain Relevance 1.02

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