INT109443

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Context Info
Confidence 0.27
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.15
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
neuron 1
Snap25 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 40 99.56 Very High Very High Very High
Dopamine 49 98.56 Very High Very High Very High
dopamine receptor 2 94.16 High High
Morphine 7 91.84 High High
Neurotransmitter 7 86.24 High High
opiate 1 77.36 Quite High
midbrain 1 76.16 Quite High
Substantia nigra 1 74.24 Quite High
Ventral tegmentum 1 72.56 Quite High
Hippocampus 1 44.40 Quite Low
Disease Link Frequency Relevance Heat
Poisoning 1 81.84 Quite High
Schizophrenia 2 69.52 Quite High
Depression 1 12.36 Low Low
Disease 8 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low
Parkinson's Disease 1 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neuron-associated mRNAs for SNAP-25 and synaptophysin, as well as the glial-associated mRNA for S100-beta and three 'housekeeping' mRNAs, were also measured.
Negative_regulation (measured) of SNAP-25 in neuron
1) Confidence 0.27 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12654507 Disease Relevance 0 Pain Relevance 0.80
Cleaved SNAP-25 level decreased to undetectable level 2 and 4 weeks after the injection.
Negative_regulation (decreased) of SNAP-25
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614467 Disease Relevance 0.08 Pain Relevance 0
However, we found that SNAP-25 protein levels were reduced by the D2-agonist, suggesting that DA may also be inhibiting some of the exocytotic machinery.
Negative_regulation (reduced) of SNAP-25 associated with dopamine and agonist
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924890 Disease Relevance 0.07 Pain Relevance 0.30

General Comments

This test has worked.

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