INT109577

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.77
Pain Relevance 5.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
neurons 4
SDH 4
muscle 2
polymodal neuron 2
afferent neurons 2
Accn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 49 100.00 Very High Very High Very High
dorsal root ganglion 20 99.68 Very High Very High Very High
spinal dorsal horn 12 99.68 Very High Very High Very High
Pain 41 99.60 Very High Very High Very High
Inflammation 18 99.56 Very High Very High Very High
Hyperalgesia 14 99.12 Very High Very High Very High
Neuropeptide 13 98.74 Very High Very High Very High
IPN 2 98.28 Very High Very High Very High
allodynia 3 97.24 Very High Very High Very High
antagonist 6 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 61 99.68 Very High Very High Very High
Pain 26 99.60 Very High Very High Very High
INFLAMMATION 11 99.56 Very High Very High Very High
Hyperalgesia 16 99.12 Very High Very High Very High
Inflammatory Pain 4 98.28 Very High Very High Very High
Neuropathic Pain 3 97.24 Very High Very High Very High
Coronary Artery Disease 1 88.28 High High
Acidosis 2 86.52 High High
Cv Unclassified Under Development 2 84.00 Quite High
Nociception 44 82.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, expressions of P2X(3) and ASIC3 also increased in muscle afferent neurons in DRGs.
Positive_regulation (increased) of Gene_expression (expressions) of ASIC3 in afferent neurons
1) Confidence 0.67 Published 2010 Journal Pain Section Abstract Doc Link 20378247 Disease Relevance 0.91 Pain Relevance 1.00
Expressions of TRPV2, P2X(3), and ASIC3 increased in all DRG neurons.
Positive_regulation (increased) of Gene_expression (Expressions) of ASIC3 in neurons associated with dorsal root ganglion
2) Confidence 0.49 Published 2010 Journal Pain Section Abstract Doc Link 20378247 Disease Relevance 0.92 Pain Relevance 1.00
ASIC3-mediated sustained depolarisation, and its regulation by neuropeptides, could thus be important in regulating polymodal neuron excitability particularly under inflammatory conditions where the expression levels of both NPFF precursor and ASIC3 are increased.
Positive_regulation (increased) of Gene_expression (expression) of ASIC3 in polymodal neuron associated with inflammation and neuropeptide
3) Confidence 0.48 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12668052 Disease Relevance 0.20 Pain Relevance 0.35
In this study, we report that another mammalian peptide neuropeptide SF (NPSF), derived from the same precursor, also considerably increases the amplitude of the sustained current of heterologously expressed ASIC3 (12-fold vs. 19- and nine-fold for FMRFamide and NPFF, respectively) with an EC(50) of approximately 50 microM.
Positive_regulation (increases) of Gene_expression (expressed) of ASIC3 associated with neuropeptide
4) Confidence 0.48 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12668052 Disease Relevance 0.25 Pain Relevance 0.36
We found profound overlap of ASIC3 and the vasodilatory peptide CGRP.
Positive_regulation (overlap) of Gene_expression (overlap) of ASIC3
5) Confidence 0.45 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.51 Pain Relevance 0.30
These relative proportions might be a slight overestimation of the situation under physiological conditions, since tracer application caused, to some extent, local inflammation, and inflammatory conditions lead to increased ASIC3 transcription in vivo and to an increased number of ASIC3 expressing neurons in vitro [46,47].
Positive_regulation (increased) of Gene_expression (expressing) of ASIC3 in neurons associated with inflammation
6) Confidence 0.43 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0.42 Pain Relevance 0.43
However, the cellular distribution and the functional consequence of increased ASIC subunit expression in the SDH remain unclear.
Positive_regulation (increased) of Gene_expression (expression) of ASIC in SDH associated with spinal dorsal horn and asic
7) Confidence 0.27 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17928456 Disease Relevance 0.61 Pain Relevance 0.99
The crucial role of ASIC3 channels in muscle-associated sensory function is underlined by the main finding of that study, which is that ASIC3 channel expression is required for the long lasting hyperalgesia produced by repeated acid injection in muscle [20].
Positive_regulation (required) of Gene_expression (expression) of ASIC3 in muscle associated with hyperalgesia
8) Confidence 0.27 Published 2005 Journal Mol Pain Section Body Doc Link PMC1283980 Disease Relevance 0.44 Pain Relevance 0.47
Previous pharmacological and behavioral studies suggest that peripheral acid-sensing ion channels (ASICs) contribute to pain sensation, and the expression of ASIC subunits is elevated in the rat spinal dorsal horn (SDH) in an inflammatory pain model.
Positive_regulation (elevated) of Gene_expression (expression) of ASIC in SDH associated with pain, ipn, spinal dorsal horn and asic
9) Confidence 0.24 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17928456 Disease Relevance 0.50 Pain Relevance 0.85

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