INT10969

Context Info Confidence 0.67 First Reported 1984 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 33 Total Number 34 Disease Relevance 16.96 Pain Relevance 8.35

cytosol (PLEK) extracellular region (PLEK) cytoplasm (PLEK)

Anatomy Link Frequency platelet 32 endothelial cells 1 erythrocyte 1 PLEK (Homo sapiens)

Pain Link Frequency Relevance Heat Clonidine 1 100.00 aspirin 66 99.76 Migraine 10 99.70 agonist 29 99.54 Analgesic 30 99.48 antagonist 8 99.30 methadone 3 99.28 ischemia 19 99.08 headache 12 98.90 Angina 34 97.80

Disease Link Frequency Relevance Heat Nicotine Addiction 515 99.86 Coronary Artery Disease 69 99.84 Headache 12 99.70 Schizophrenia 13 99.44 Thrombosis 52 99.28 Cardiovascular Disease 5 99.24 Disorder Of Lipid Metabolism 144 99.22 Cv Unclassified Under Development 9 99.08 Headache Disorders 6 98.90 Cv General 3 Under Development 32 97.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Relative to placebo administration there was a statistically significant increase in platelet factor 4, ?

Positive_regulation (increase) of platelet in platelet

1) Confidence 0.67 Published 2007 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2042971 Disease Relevance 0.65 Pain Relevance 0.52

Our previous study showed that drug-free schizophrenic patients had a significant increase in maximum numbers (B(max)) of platelet 5-HT(2A) receptors that declined to normal level after treatment with different neuroleptic drugs.

Positive_regulation (increase) of platelet in platelet associated with schizophrenia

2) Confidence 0.67 Published 2002 Journal Neurochem. Int. Section Abstract Doc Link 12106771 Disease Relevance 0.49 Pain Relevance 0.26

An alteration in serotonin concentration has been found in patients with chronic headache caused by abuse of analgesic substances as well as an up-regulation of 5HT2 platelet receptors, which has been correlated with chronicization of the headache.

Positive_regulation (up-regulation) of platelet in platelet associated with headache disorders, analgesic, headache and serotonin

3) Confidence 0.67 Published 1999 Journal Cephalalgia Section Abstract Doc Link 10595291 Disease Relevance 0.56 Pain Relevance 0.67

The final common pathway to platelet aggregation is the activation of the platelet glycoprotein (GP) IIb-IIIa receptor, which allows the cross-linking of adjacent platelets by the adhesive plasma proteins fibrinogen and von Willebrand's factor.

Positive_regulation (activation) of platelet in platelet

4) Confidence 0.67 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9291240 Disease Relevance 0.77 Pain Relevance 0.11

This smoking-induced long-lasting effect was due to demethylation of the MAOB gene promoter which resulted in a persistent high protein concentration of platelet MAO-B.

Positive_regulation (concentration) of platelet in platelet associated with nicotine addiction

5) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 0.87 Pain Relevance 0

These results confirm previous reports of an association between suicidality and platelet 5-HT2 receptor upregulation.

Positive_regulation (upregulation) of platelet in platelet

6) Confidence 0.67 Published 1997 Journal Biol. Psychiatry Section Abstract Doc Link 9018388 Disease Relevance 0.21 Pain Relevance 0.38

A marked increase in platelet 5-HT2 receptors at baseline was observed in suicidal depressed patients compared to those with no suicidal ideation and healthy controls.

Positive_regulation (increase) of platelet in platelet

7) Confidence 0.67 Published 1997 Journal Biol. Psychiatry Section Abstract Doc Link 9018388 Disease Relevance 0.24 Pain Relevance 0.42

Migraine patients show increased platelet vasopressin receptors.

Positive_regulation (increased) of platelet in platelet associated with migraine

8) Confidence 0.67 Published 1996 Journal Headache Section Title Doc Link 8990597 Disease Relevance 0.75 Pain Relevance 0.75

Menadione produced a concentration-dependent and time-dependent stimulation of platelet 86Rb+ uptake.

Positive_regulation (stimulation) of platelet in platelet

9) Confidence 0.67 Published 1991 Journal Biochem. Pharmacol. Section Abstract Doc Link 1848980 Disease Relevance 0.13 Pain Relevance 0.14

In an in-vitro study thrombin in a concentration similar to that found in vivo significantly increased the number of platelet TxA2/PGH2 receptors (p < 0.01), whereas heparin did not affect TxA2/PGH2 receptors.

Positive_regulation (increased) of platelet in platelet

10) Confidence 0.67 Published 1995 Journal Am. Heart J. Section Abstract Doc Link 7732975 Disease Relevance 0.37 Pain Relevance 0.54

Platelet 5-HT2 receptor density was increased and the ligand affinity was decreased during mianserin administration.

Positive_regulation (increased) of Platelet in Platelet

11) Confidence 0.49 Published 1993 Journal Life Sci. Section Abstract Doc Link 8326822 Disease Relevance 0 Pain Relevance 0.36

Glycoprotein (GP) IIb/IIIa receptor antagonists inhibit the binding of ligands to activated platelet GP IIb/IIIa receptors and, therefore, prevent the formation of platelet thrombi.

Positive_regulation (activated) of platelet in platelet associated with antagonist

12) Confidence 0.49 Published 2007 Journal Expert Opin Pharmacother Section Abstract Doc Link 17516878 Disease Relevance 0.05 Pain Relevance 0.05

Because aspirin completely inactivates platelet COX-1, antiplatelet benefits last for the lifetime of the platelet and are only attenuated by the regeneration of new platelets.

Positive_regulation (inactivates) of platelet in platelet associated with aspirin

13) Confidence 0.49 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2257951 Disease Relevance 0.30 Pain Relevance 1.28

Paradoxical activation of major platelet receptors in the methadone-maintained patients after single pill of aspirin.

Positive_regulation (activation) of platelet in platelet associated with aspirin and methadone

14) Confidence 0.49 Published 2001 Journal Thromb. Res. Section Title Doc Link 11728532 Disease Relevance 0.37 Pain Relevance 0.54

These data agree with most previous studies, suggesting that a subset of platelet alpha 2 adrenoceptors, recognized by clonidine and its derivative para-aminoclonidine, is upregulated in depressed patients.

Positive_regulation (upregulated) of platelet in platelet associated with clonidine

15) Confidence 0.49 Published 1990 Journal Neuropsychopharmacology Section Abstract Doc Link 1973039 Disease Relevance 0 Pain Relevance 0.14

The final step of platelet aggregation is mediated through the platelet integrin glycoprotein IIb/IIIa (GP IIb/IIIa), while abciximab (ReoPro) is one of the most potent inhibitors of this receptor.

Positive_regulation (mediated) of platelet in platelet

16) Confidence 0.49 Published 1999 Journal Cardiovasc. Res. Section Abstract Doc Link 10536703 Disease Relevance 0.17 Pain Relevance 0.28

We studied the ischemia-induced alterations in fibrinogen binding to activated platelet GP IIb/IIIa receptors and CD 62p expression.

Positive_regulation (activated) of platelet in platelet associated with ischemia

17) Confidence 0.49 Published 1999 Journal Thromb. Res. Section Abstract Doc Link 9950258 Disease Relevance 0.85 Pain Relevance 0.24

Both patients were confirmed to have oxaliplatin-dependent IgG platelet antibodies.

Positive_regulation (dependent) of platelet in platelet

18) Confidence 0.49 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2859393 Disease Relevance 0.43 Pain Relevance 0

Both patients were confirmed to have strong oxaliplatin-induced IgG platelet-reactive antibodies.

Positive_regulation (induced) of platelet in platelet

19) Confidence 0.49 Published 2010 Journal J Hematol Oncol Section Abstract Doc Link PMC2859393 Disease Relevance 0.99 Pain Relevance 0

, platelet-derived epidermal growth factor (PDEGF), and platelet-derived angiogenesis factor (PDAF) [51].

Positive_regulation (derived) of platelet in platelet

20) Confidence 0.49 Published 2010 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2844688 Disease Relevance 0.82 Pain Relevance 0

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