INT10977

Context Info Confidence 0.34 First Reported 1992 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.13 Pain Relevance 0.03

extracellular region (ENPP3)

Anatomy Link Frequency basophils 2 ENPP3 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 6 66.52 Kinase C 17 44.00 anesthesia 1 25.00 agonist 7 5.00 cytokine 1 5.00 Analgesic 1 5.00 withdrawal 1 5.00 Bioavailability 1 5.00 Calcium channel 1 5.00

Disease Link Frequency Relevance Heat Hypersensitivity 14 67.00 INFLAMMATION 6 66.52 Myocardial Infarction 2 30.80 Hypertension 1 5.00 Apoptosis 1 5.00 Disease Susceptibility 1 5.00 Cancer 1 5.00 Chronic Disease 1 5.00 Anaphylaxis 1 5.00 Leukemia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Quercetin inhibited the expression of CD63 and CD203c and the histamine release in basophils activated with anti-IgE or with the ionophore: the IC50 in the anti-IgE model was higher than in the ionophore model and the effects were more pronounced for CD63 than for CD203c.

Negative_regulation (inhibited) of Gene_expression (expression) of CD203c in basophils

1) Confidence 0.34 Published 2010 Journal Clin Mol Allergy Section Abstract Doc Link PMC2949734 Disease Relevance 0.13 Pain Relevance 0.03

R 80122 is a newly synthesized, selective phosphodiesterase III inhibitor.

Negative_regulation (inhibitor) of Gene_expression (synthesized) of phosphodiesterase III

2) Confidence 0.02 Published 1992 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 1530374 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.