INT109840

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Context Info
Confidence 0.74
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.01
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkce) Golgi apparatus (Prkce) endoplasmic reticulum (Prkce)
enzyme binding (Prkce) cytoplasm (Prkce) cytosol (Prkce)
Anatomy Link Frequency
plasma 1
neurons 1
nociceptor 1
Prkce (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 13 99.82 Very High Very High Very High
Inflammation 8 99.36 Very High Very High Very High
qutenza 8 98.20 Very High Very High Very High
nociceptor 11 98.16 Very High Very High Very High
Hyperalgesia 13 96.52 Very High Very High Very High
antagonist 2 93.60 High High
Pain 7 91.84 High High
Eae 2 91.08 High High
Root ganglion neuron 2 88.24 High High
Spinal cord 1 86.48 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 99.36 Very High Very High Very High
Nociception 7 98.52 Very High Very High Very High
Hyperalgesia 13 96.52 Very High Very High Very High
Pain 3 91.84 High High
Injury 2 91.08 High High
Ganglion Cysts 7 87.84 High High
Herpes Simplex Virus 1 87.00 High High
Nervous System Injury 1 75.00 Quite High
Neuropathic Pain 1 54.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, estrogen applied alone leads to a brief translocation of PKCepsilon.
Localization (translocation) of PKCepsilon
1) Confidence 0.74 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16836642 Disease Relevance 0.66 Pain Relevance 0.45
In contrast, G-1, a specific agonist of the recently identified G-protein-coupled estrogen receptor, GPR30, induced PKCepsilon translocation.
Localization (translocation) of PKCepsilon associated with agonist
2) Confidence 0.22 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18371086 Disease Relevance 0.29 Pain Relevance 0.51
We found estrogen-induced as well as GPR30-agonist-induced PKCepsilon translocation to be restricted to the subgroup of nociceptive neurons positive for isolectin IB4 from Bandeiraea simplicifolia.
Localization (translocation) of PKCepsilon in neurons associated with nociception and agonist
3) Confidence 0.22 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18371086 Disease Relevance 0.33 Pain Relevance 0.67
Inflammatory mediator-induced activation of PKCepsilon and subsequent sensitization of VR1 to noxious stimuli by PKCepsilon may be involved in nociceptor sensitization.
Localization (sensitization) of PKCepsilon in nociceptor associated with inflammation and nociceptor
4) Confidence 0.19 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694383 Disease Relevance 1.30 Pain Relevance 0.90
Phorbol esters induced translocation of endogenous PKCepsilon to the plasma membrane and thereby enhanced CAPS currents.
Localization (translocation) of PKCepsilon in plasma associated with qutenza
5) Confidence 0.19 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973552 Disease Relevance 0.43 Pain Relevance 0.92

General Comments

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