INT110016

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Context Info
Confidence 0.28
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.47
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
neuronal 2
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 1 100.00 Very High Very High Very High
Neuropathic pain 1 99.68 Very High Very High Very High
Neurotransmitter 1 98.90 Very High Very High Very High
nMDA receptor 2 97.76 Very High Very High Very High
Morphine 86 96.88 Very High Very High Very High
opioid receptor 84 95.36 Very High Very High Very High
Spinal cord 3 90.48 High High
Analgesic 19 88.72 High High
Pain 2 87.36 High High
agonist 4 85.68 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 99.68 Very High Very High Very High
Pain 4 87.36 High High
INFLAMMATION 1 85.24 High High
Apoptosis 1 69.84 Quite High
Urological Neuroanatomy 18 68.48 Quite High
Death 1 58.32 Quite High
Nociception 7 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Intractable Pain 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, transient Akt-activating phosphorylation of nNOS Ser1417 [38] was followed by a robust increase in CaMKII-mediated inactivating phosphorylation of nNOS Ser847 [57].
Negative_regulation (inactivating) of Phosphorylation (phosphorylation) of nNOS
1) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.20 Pain Relevance 1.07
Immunophilin ligands, cyclosporine A and FK506 (tacrolimus), besides their immunosuppressive action, have several effects on different neural functions, such as modulation of the release of many neurotransmitters, the reduction of nitric oxide (NO) production by the inhibition of dephosphorylation of neuronal nitric oxide synthase (nNOS) and the alteration of the expression of certain genes.
Negative_regulation (inhibition) of Phosphorylation (dephosphorylation) of neuronal nitric oxide synthase in neuronal associated with neurotransmitter and neuronal nitric oxide synthase
2) Confidence 0.16 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706476 Disease Relevance 0 Pain Relevance 0.62
These phosphorylation and nNOS activity visualized by NADPH-diaphorase histochemistry were blocked by indomethacin, a PG synthesis inhibitor.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of nNOS
3) Confidence 0.14 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16188227 Disease Relevance 0.27 Pain Relevance 0.47

General Comments

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