INT110039

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 38
Total Number 41
Disease Relevance 34.54
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppb) extracellular region (Nppb) nucleus (Nppb)
cytoplasm (Nppb)
Anatomy Link Frequency
plasma 6
heart 4
cardiomyocyte 2
coronary artery 1
chest 1
Nppb (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 27 98.52 Very High Very High Very High
Angina 66 98.28 Very High Very High Very High
Inflammation 15 92.44 High High
imagery 5 87.52 High High
beta blocker 5 78.40 Quite High
Inflammatory marker 2 75.00 Quite High
Inflammatory stimuli 1 68.36 Quite High
anesthesia 3 10.00 Low Low
Pain 15 5.00 Very Low Very Low Very Low
Bioavailability 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 92 100.00 Very High Very High Very High
Mitral Valve Insufficiency 159 99.96 Very High Very High Very High
Sickle Cell Anemia 135 99.84 Very High Very High Very High
Acute Coronary Syndrome 104 99.76 Very High Very High Very High
Disease 4 99.76 Very High Very High Very High
Anaemia 22 99.60 Very High Very High Very High
Hypertension 336 99.12 Very High Very High Very High
Heart Rate Under Development 80 98.88 Very High Very High Very High
Coronary Artery Disease 60 98.84 Very High Very High Very High
Coronary Heart Disease 25 98.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, BNP and NT-proBNP levels are increased acutely in proportion to the magnitude of the inducible perfusion defect observed during stress testing, suggesting that BNP and NT-proBNP are markers of acute ischemia.
Positive_regulation (increased) of BNP associated with stress and ischemia
1) Confidence 0.53 Published 2005 Journal Scand. J. Clin. Lab. Invest. Suppl. Section Abstract Doc Link 16112956 Disease Relevance 1.60 Pain Relevance 0.29
Plasma B-type natriuretic peptide (BNP) levels have been reported to be elevated in various types of cardiac disorders and in precursors of CHF.
Positive_regulation (elevated) of BNP in Plasma associated with natriuresis
2) Confidence 0.49 Published 2005 Journal International heart journal Section Abstract Doc Link 16043943 Disease Relevance 0.67 Pain Relevance 0
The sensitivity, specificity, positive predictive accuracy (PPA) and negative predictive accuracy (NPA) were all calculated for BNP, TnT and for the composite of BNP and TnT.
Positive_regulation (calculated) of BNP
3) Confidence 0.40 Published 2007 Journal QJM Section Body Doc Link 18089541 Disease Relevance 0.14 Pain Relevance 0
The sensitivity, specificity, positive predictive accuracy (PPA) and negative predictive accuracy (NPA) were all calculated for BNP, TnT and for the composite of BNP and TnT.
Positive_regulation (calculated) of BNP
4) Confidence 0.40 Published 2007 Journal QJM Section Body Doc Link 18089541 Disease Relevance 0.14 Pain Relevance 0
The results of the present study suggest that an elevated BNP level on arrival in the ICU is an independent predictor of postoperative heart failure after aortic valve replacement.
Positive_regulation (elevated) of BNP in heart
5) Confidence 0.39 Published 2009 Journal J. Cardiothorac. Vasc. Anesth. Section Body Doc Link 19167912 Disease Relevance 0 Pain Relevance 0
In the authors' opinion, an increased BNP level on arrival in the ICU may support early diagnosis and allow optimal management of heart failure after aortic valve replacement.


Positive_regulation (increased) of BNP in heart
6) Confidence 0.39 Published 2009 Journal J. Cardiothorac. Vasc. Anesth. Section Body Doc Link 19167912 Disease Relevance 0 Pain Relevance 0
Elevated postoperative BNP levels were identified as an independent predictor of postoperative heart failure: BNP >82 pg/mL (p = 0.004) and BNP >133 pg/mL (p = 0.013).
Positive_regulation (Elevated) of BNP in heart
7) Confidence 0.39 Published 2009 Journal J. Cardiothorac. Vasc. Anesth. Section Body Doc Link 19167912 Disease Relevance 0 Pain Relevance 0
When normal levels were adjusted for age and gender, 9 (80%) patients had elevated BNP.
Positive_regulation (elevated) of BNP
8) Confidence 0.36 Published 2004 Journal Kardiol Pol Section Body Doc Link 15883593 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: BNP level is increased in some patients with acute perimyocarditis.
Positive_regulation (increased) of BNP
9) Confidence 0.36 Published 2004 Journal Kardiol Pol Section Body Doc Link 15883593 Disease Relevance 0 Pain Relevance 0
BNP elevation is probably associated with hemodynamical stress caused by transient contractility abnormalities.
Positive_regulation (elevation) of BNP
10) Confidence 0.36 Published 2004 Journal Kardiol Pol Section Body Doc Link 15883593 Disease Relevance 0 Pain Relevance 0
The proBNP hormone is cleaved into the biologically active BNP and an easily measurable inactive amino-terminal proBNP.
Positive_regulation (active) of BNP
11) Confidence 0.34 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 2.44 Pain Relevance 0
The proBNP hormone is cleaved into the biologically active BNP and an easily measurable inactive amino-terminal proBNP.
Positive_regulation (active) of proBNP
12) Confidence 0.34 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 2.53 Pain Relevance 0
BNP was most frequently measured in patients presenting with high-risk characteristics, but the association of incremental increases in BNP levels with higher mortality rates was similar across risk categories.
Positive_regulation (increases) of BNP
13) Confidence 0.34 Published 2007 Journal Am. J. Cardiol. Section Abstract Doc Link 18082516 Disease Relevance 0.47 Pain Relevance 0
In conclusion, elevated BNP indicates progressively worse survival in patients with AS treated medically.
Positive_regulation (elevated) of BNP associated with cv unclassified under development
14) Confidence 0.33 Published 2005 Journal Am. J. Cardiol. Section Abstract Doc Link 16275196 Disease Relevance 0.57 Pain Relevance 0.06
Subjects with elevated BNP were selected independently on the basis of plasma levels (n = 112).
Positive_regulation (elevated) of BNP in plasma
15) Confidence 0.33 Published 2005 Journal International heart journal Section Abstract Doc Link 16043943 Disease Relevance 0.92 Pain Relevance 0.09
Elevated plasma levels of B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-pro-BNP) are seen in the setting of cardiac ischemia and are associated with adverse outcomes in patients with coronary artery disease.
Positive_regulation (Elevated) of BNP in plasma associated with natriuresis, coronary artery disease and ischemia
16) Confidence 0.32 Published 2005 Journal Am. J. Cardiol. Section Abstract Doc Link 16253599 Disease Relevance 0.80 Pain Relevance 0.08
Elevated plasma levels of B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-pro-BNP) are seen in the setting of cardiac ischemia and are associated with adverse outcomes in patients with coronary artery disease.
Positive_regulation (Elevated) of BNP in plasma associated with natriuresis, coronary artery disease and ischemia
17) Confidence 0.32 Published 2005 Journal Am. J. Cardiol. Section Abstract Doc Link 16253599 Disease Relevance 0.81 Pain Relevance 0.08
Elevated plasma levels of B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-pro-BNP) are seen in the setting of cardiac ischemia and are associated with adverse outcomes in patients with coronary artery disease.
Positive_regulation (Elevated) of BNP in plasma associated with natriuresis, coronary artery disease and ischemia
18) Confidence 0.32 Published 2005 Journal Am. J. Cardiol. Section Abstract Doc Link 16253599 Disease Relevance 0.81 Pain Relevance 0.08
One standard deviation (SD) decrease in ejection fraction implied the most prominent increase in risk of future CV events (HR 1.69; p < 0.001) followed by one SD increase in BNP (HR 1.53; p < 0.001).
Positive_regulation (increase) of BNP
19) Confidence 0.32 Published 2006 Journal J. Am. Coll. Cardiol. Section Body Doc Link 16458135 Disease Relevance 0.05 Pain Relevance 0
RESULTS: BNP concentrations were significantly elevated in patients with future CV events (median [25th/75th interquartile range] 119.2 [43.6/300.4] pg/ml vs. 36.2 [11.3/94.6] pg/ml; p < 0.001).
Positive_regulation (elevated) of BNP
20) Confidence 0.32 Published 2006 Journal J. Am. Coll. Cardiol. Section Body Doc Link 16458135 Disease Relevance 0.17 Pain Relevance 0

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