INT11014

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Context Info
Confidence 0.81
First Reported 1992
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 72
Total Number 79
Disease Relevance 26.35
Pain Relevance 25.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1)
nucleolus (CREB1) nucleus (CREB1) transcription factor binding (CREB1)
Anatomy Link Frequency
dorsal horn 8
chondrocytes 2
spinal cord 2
neuronal 2
photoreceptors 2
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 50 100.00 Very High Very High Very High
adenocard 9 100.00 Very High Very High Very High
agonist 256 99.76 Very High Very High Very High
Spinal cord 28 99.68 Very High Very High Very High
spinal dorsal horn 27 99.68 Very High Very High Very High
long-term potentiation 197 99.52 Very High Very High Very High
alcohol 502 99.50 Very High Very High Very High
Desipramine 24 99.50 Very High Very High Very High
Morphine 15 99.44 Very High Very High Very High
Neuropathic pain 58 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Colon Cancer 15 99.70 Very High Very High Very High
Nervous System Injury 52 99.56 Very High Very High Very High
Cystitis 27 99.54 Very High Very High Very High
Apoptosis 50 99.44 Very High Very High Very High
Neuropathic Pain 84 99.40 Very High Very High Very High
Stress 284 98.96 Very High Very High Very High
Neuritis 4 98.88 Very High Very High Very High
Multiple Sclerosis 22 98.44 Very High Very High Very High
Anxiety Disorder 170 98.40 Very High Very High Very High
Pain 64 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of chondrocytes with beta-endorphin resulted in decreased phosphorylation of the transcription factor cAMP responsive element binding protein (CREB).
Phosphorylation (phosphorylation) of cAMP responsive element binding protein in chondrocytes
1) Confidence 0.81 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 14575714 Disease Relevance 0.33 Pain Relevance 0.63
Stimulation of chondrocytes with beta-endorphin resulted in decreased phosphorylation of the transcription factor cAMP responsive element binding protein (CREB).
Phosphorylation (phosphorylation) of CREB in chondrocytes
2) Confidence 0.81 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 14575714 Disease Relevance 0.33 Pain Relevance 0.63
First, the results of immunohistochemical study showed that phosphorylated cyclic AMP response element-binding protein, but not cyclic AMP response element-binding protein, increased bilaterally in the spinal dorsal horn 14 days following spared nerve injury, indicating a possible contribution of phosphorylated cyclic AMP response element-binding protein in spared nerve injury.
Phosphorylation (phosphorylated) of cyclic AMP response element-binding protein in dorsal horn associated with nervous system injury and spinal dorsal horn
3) Confidence 0.81 Published 2006 Journal Neuroscience Section Abstract Doc Link 16515839 Disease Relevance 0.93 Pain Relevance 0.70
First, the results of immunohistochemical study showed that phosphorylated cyclic AMP response element-binding protein, but not cyclic AMP response element-binding protein, increased bilaterally in the spinal dorsal horn 14 days following spared nerve injury, indicating a possible contribution of phosphorylated cyclic AMP response element-binding protein in spared nerve injury.
Phosphorylation (phosphorylated) of cyclic AMP response element-binding protein in dorsal horn associated with nervous system injury and spinal dorsal horn
4) Confidence 0.81 Published 2006 Journal Neuroscience Section Abstract Doc Link 16515839 Disease Relevance 0.94 Pain Relevance 0.71
Our data demonstrate a close association between the expression of behavioral hypersensitivity and cyclic AMP response element-binding protein activation in the spinal dorsal horn following spared nerve injury, supporting the notion that phosphorylated cyclic AMP response element-binding protein may play an important role in the maintenance of chronic neuropathic pain.
Phosphorylation (phosphorylated) of cyclic AMP response element-binding protein in dorsal horn associated with nervous system injury, spinal dorsal horn, hypersensitivity and neuropathic pain
5) Confidence 0.81 Published 2006 Journal Neuroscience Section Abstract Doc Link 16515839 Disease Relevance 0.62 Pain Relevance 0.40
Western blot results showed that the alleviation in intensity of behavioral performance was accompanied by a significant reduction of total cyclic AMP response element-binding protein and phosphorylated cyclic AMP response element-binding protein in the spinal dorsal horn.
Phosphorylation (phosphorylated) of cyclic AMP response element-binding protein in dorsal horn associated with spinal dorsal horn
6) Confidence 0.81 Published 2006 Journal Neuroscience Section Abstract Doc Link 16515839 Disease Relevance 0.64 Pain Relevance 0.53
The present study examined the roles of cyclic AMP response element-binding protein and of the phosphorylated cyclic AMP response element-binding protein in the maintenance of mechanical and cold allodynia induced by a neuropathic pain model, "spared nerve injury," in rats.
Phosphorylation (phosphorylated) of cyclic AMP response element-binding protein in nerve associated with nervous system injury, allodynia and neuropathic pain
7) Confidence 0.81 Published 2006 Journal Neuroscience Section Abstract Doc Link 16515839 Disease Relevance 0.86 Pain Relevance 0.66
The RHC associated variants, Arg151Cys, Arg160Trp and Asp294His, demonstrated agonist-mediated increases in cAMP and phosphorylation of cAMP-responsive element-binding protein (CREB).
Phosphorylation (phosphorylation) of CREB associated with agonist
8) Confidence 0.78 Published 2005 Journal Peptides Section Abstract Doc Link 15992961 Disease Relevance 0.16 Pain Relevance 0.38
Melanoma cells homozygous for either the Arg151Cys variant or consensus sequence both elicited CREB phosphorylation in response to alpha-MSH in the presence of IBMX.
Phosphorylation (phosphorylation) of CREB associated with skin cancer
9) Confidence 0.78 Published 2005 Journal Peptides Section Abstract Doc Link 15992961 Disease Relevance 0.17 Pain Relevance 0.33
The RHC associated variants, Arg151Cys, Arg160Trp and Asp294His, demonstrated agonist-mediated increases in cAMP and phosphorylation of cAMP-responsive element-binding protein (CREB).
Phosphorylation (phosphorylation) of cAMP-responsive element-binding protein associated with agonist
10) Confidence 0.78 Published 2005 Journal Peptides Section Abstract Doc Link 15992961 Disease Relevance 0.16 Pain Relevance 0.38
Moreover, in HEK-OP3 and SH-SY5Y cells, increased nuclear CaM content was associated with enhanced phosphorylation of the nuclear transcription factor cyclic AMP-responsive element-binding protein.
Phosphorylation (phosphorylation) of cyclic AMP-responsive element-binding protein in SH-SY5Y associated with opioid
11) Confidence 0.73 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737597 Disease Relevance 0.09 Pain Relevance 1.23
Treatment with several different cAMP agonists stimulated phosphorylation of CRE-binding protein (CREB) and activated expression of c-IAP2 in a CREB-dependent manner.
Phosphorylation (phosphorylation) of CREB associated with agonist
12) Confidence 0.64 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.81 Pain Relevance 0.14
We conclude that cAMP can induce c-IAP2 expression in colon cancer cells through CREB phosphorylation and CRE-dependent transcription in a manner that involves activation of ERK1/2 and p38 MAPK.
Phosphorylation (phosphorylation) of CREB in colon associated with colon cancer
13) Confidence 0.64 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.73 Pain Relevance 0.09
Studies with pharmacological inhibitors revealed that cAMP-dependent phosphorylation of CREB required activation of ERK1/2 and p38 MAPK but was largely independent of protein kinase A.
Phosphorylation (phosphorylation) of CREB
14) Confidence 0.64 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.84 Pain Relevance 0.13
First, the results of immunohistochemical study showed that phosphorylated cyclic AMP response element-binding protein, but not cyclic AMP response element-binding protein, increased bilaterally in the spinal dorsal horn 14 days following spared nerve injury, indicating a possible contribution of phosphorylated cyclic AMP response element-binding protein in spared nerve injury.
Phosphorylation (phosphorylated) of cyclic AMP response element-binding protein in dorsal horn associated with nervous system injury and spinal dorsal horn
15) Confidence 0.62 Published 2006 Journal Neuroscience Section Abstract Doc Link 16515839 Disease Relevance 0.91 Pain Relevance 0.68
The present study examined the roles of cyclic AMP response element-binding protein and of the phosphorylated cyclic AMP response element-binding protein in the maintenance of mechanical and cold allodynia induced by a neuropathic pain model, "spared nerve injury," in rats.
Phosphorylation (phosphorylated) of cyclic AMP response element-binding protein in nerve associated with nervous system injury, allodynia and neuropathic pain
16) Confidence 0.62 Published 2006 Journal Neuroscience Section Abstract Doc Link 16515839 Disease Relevance 0.85 Pain Relevance 0.66
Alcohol may disrupt orientation selectivity by acutely suppressing NMDA receptor function [10], [23], [68] while enhancing GABA receptor function [69] thereby affecting CREB phosphorylation [70]–[72].
Phosphorylation (phosphorylation) of CREB associated with gaba receptor, nmda receptor and alcohol
17) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0.40
To further evaluate changes in CREB phosphorylation we compared pCREB/GAPDH levels of Ethanol and Ethanol+Vinpocetine animals to their controls (Figure 4c).
Phosphorylation (phosphorylation) of CREB
18) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0
Quantification of immunoblots optical densities (Odyssey Application Software, 2.0) confirmed that vinpocetine treatment significantly increased CREB phosphorylation in Ethanol treated animals without affecting total CREB levels (Figure 4b).
Phosphorylation (phosphorylation) of CREB
19) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0
This effect of DMI was not dependent upon activity at the levels of the beta2 receptor, cAMP accumulation or phosphorylation of the transcription factor, cAMP response element binding protein (CREB).
Phosphorylation (phosphorylation) of cAMP response element binding protein associated with desipramine
20) Confidence 0.60 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16036225 Disease Relevance 0 Pain Relevance 0.43

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