INT110179

Context Info Confidence 0.36 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 11 Total Number 11 Disease Relevance 5.25 Pain Relevance 2.38

cytosol (MAPK14) nucleoplasm (MAPK14) signal transduction (MAPK14) nucleus (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14)

Anatomy Link Frequency chondrocytes 2 vessels 2 MAPK14 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 9 99.46 Osteoarthritis 216 98.48 Abeta 8 97.88 Nicotine 96 94.96 Cannabinoid 1 86.44 antagonist 8 81.20 agonist 12 77.12 qutenza 2 76.40 Inflammation 52 71.72 bradykinin 41 71.20

Disease Link Frequency Relevance Heat Cancer 106 99.24 Osteoarthritis 220 98.48 Reprotox - General 1 58 97.00 Apoptosis 52 96.28 Injury 4 94.32 Metastasis 44 91.44 Asthma 15 91.40 Sepsis 1 90.92 Camurati-engelmann Disease 1 90.88 Shock 3 88.12

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

-induced phosphorylation of p38-MAPK was inhibited in chondrocytes pre-treated with PE (Figure 4a).

Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of p38 in chondrocytes

1) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.73 Pain Relevance 0.37

Suppression of AP-1 was associated with altered phosphorylation of p38 mitogen-activated protein kinases.

Negative_regulation (altered) of Phosphorylation (phosphorylation) of p38

2) Confidence 0.22 Published 2004 Journal Anesthesiology Section Body Doc Link 15329596 Disease Relevance 0 Pain Relevance 0

AEA triggered phosphorylation of c-Jun NH(2)-terminal kinase (JNK) and p38 mitogen activated protein kinase.

Negative_regulation (triggered) of Phosphorylation (phosphorylation) of p38

3) Confidence 0.21 Published 2003 Journal Thromb. Haemost. Section Abstract Doc Link 12719786 Disease Relevance 0.82 Pain Relevance 0.20

At this time (45 min), both p38 kinase and Akt phosphorylated forms were diminished.

Negative_regulation (diminished) of Phosphorylation (phosphorylated) of p38 kinase

4) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.39 Pain Relevance 0.04

Both aspirin-mediated permeability and phosphorylation of p38 MAPK were significantly attenuated by SB-203580 (a p38 MAPK inhibitor) but not by U-0126 (a MEK1 inhibitor) or SP-600125 (a JNK inhibitor).

Negative_regulation (attenuated) of Phosphorylation (phosphorylation) of p38 associated with aspirin

5) Confidence 0.18 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 18667601 Disease Relevance 0.14 Pain Relevance 0.40

Cannabidiol effect was mediated through the inhibition of phosphorylated form of p38 MAP kinase and transcription factor nuclear factor-kappaB activation in a concentration-dependent manner.

Negative_regulation (inhibition) of Phosphorylation (phosphorylated) of p38 MAP kinase

6) Confidence 0.12 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16490313 Disease Relevance 0.59 Pain Relevance 0.35

Cannabidiol effect was mediated through the inhibition of phosphorylated form of p38 MAP kinase and transcription factor nuclear factor-kappaB activation in a concentration-dependent manner.

Negative_regulation (inhibition) of Phosphorylation (form) of p38 MAP kinase

7) Confidence 0.12 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16490313 Disease Relevance 0.59 Pain Relevance 0.35

M, SP600125 selectively inhibits the phosphorylation of JNK, but not ERK1/2 or p38 in vessels [39].

Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of p38 in vessels

8) Confidence 0.09 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.16 Pain Relevance 0.33

activated the ERK1/2 and p38 pathways (Figures 3a and 3b, respectively), diacerein and rhein both significantly inhibited the phosphorylation levels of ERK1/2 (Figure 3a) and both decreased the p38 phosphorylation with statistical significance reached for rhein.

Negative_regulation (decreased) of Phosphorylation (phosphorylation) of p38

9) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.38 Pain Relevance 0.16

activated the ERK1/2 and p38 pathways (Figures 3a and 3b, respectively), diacerein and rhein both significantly inhibited the phosphorylation levels of ERK1/2 (Figure 3a) and both decreased the p38 phosphorylation with statistical significance reached for rhein.

Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of p38

10) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.46 Pain Relevance 0.20

Importantly, genistein decreased phosphorylation of both p38 MAPK and HSP27 in tumor tissue, consistent with inhibition of MEK4.

Negative_regulation (decreased) of Phosphorylation (phosphorylation) of p38 associated with cancer

11) Confidence 0.07 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.99 Pain Relevance 0

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