INT110180

Context Info Confidence 0.80 First Reported 2001 Last Reported 2010 Negated 1 Speculated 2 Reported most in Body Documents 23 Total Number 25 Disease Relevance 11.21 Pain Relevance 3.83

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) nucleus (JUN) DNA binding (JUN)

Anatomy Link Frequency nucleus 3 macrophages 1 monocytes 1 brain 1 ASK 1 JUN (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammatory mediators 16 98.76 metalloproteinase 310 98.72 cytokine 205 97.00 Inflammation 316 96.60 Inflammatory response 41 96.20 Visceral pain 1 93.84 long-term potentiation 1 87.24 Cannabinoid 9 86.04 aspirin 13 84.40 c fibre 10 84.32

Disease Link Frequency Relevance Heat Stress 152 99.84 Apoptosis 353 99.36 Cancer 136 98.60 INFLAMMATION 390 98.36 Dna Damage 1 97.84 Acquired Immune Deficiency Syndrome Or Hiv Infection 501 97.00 Carcinoma 98 95.52 Shock 5 94.96 Injury 92 93.92 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 1 93.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

AEA triggered phosphorylation of c-Jun NH(2)-terminal kinase (JNK) and p38 mitogen activated protein kinase.

Phosphorylation (phosphorylation) of c-Jun

1) Confidence 0.80 Published 2003 Journal Thromb. Haemost. Section Abstract Doc Link 12719786 Disease Relevance 0.81 Pain Relevance 0.19

Extracellular signal-regulated kinase 1 and 2, p38 and stress-activated protein kinase/c-Jun-NH(2)-kinase were not phosphorylated after omega-6 fatty acid addition.

Neg (not) Phosphorylation (phosphorylated) of c-Jun associated with stress

2) Confidence 0.80 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16452198 Disease Relevance 0.26 Pain Relevance 0.24

In the present study we used immunoblotting techniques to examine the effects of acute and repeated restraint stress on the phosphorylation state of three MAPKs, the extracellular signal-regulated kinase Erk1/2, c-Jun-N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38 MAPK, in different brain regions.

Spec (examine) Phosphorylation (phosphorylation) of c-Jun in brain associated with stress

3) Confidence 0.79 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850571 Disease Relevance 0.46 Pain Relevance 0.18

p-c-Jun, phosphorylated c-Jun

Phosphorylation (phosphorylated) of p-c-Jun

4) Confidence 0.62 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 1.00 Pain Relevance 0.65

The shift of redox balance towards oxidative conditions facilitates phosphorylation and activation of c-Jun N-terminal kinase (JNK), a kinase that promotes Jun translocation into the nucleus.

Phosphorylation (phosphorylation) of c-Jun in nucleus

5) Confidence 0.54 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.60 Pain Relevance 0.14

p-c-Jun, phosphorylated c-Jun

Phosphorylation (phosphorylated) of Jun

6) Confidence 0.54 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.94 Pain Relevance 0.63

Vpr activates the DNA binding activity of AP-1 by promoting the phosphorylation of cFos and cJun in monocytes and macrophages [267].

Phosphorylation (phosphorylation) of cJun in monocytes

7) Confidence 0.44 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.61 Pain Relevance 0

-induced MAPK activation, we investigated the phosphorylation of c-jun amino-terminal kinase (JNK), p38 and extracellular signal-regulated kinase (ERK)1/2 after pretreatment with glucosamine and stimulation with IL-1?.

Spec (investigated) Phosphorylation (phosphorylation) of c-jun

8) Confidence 0.37 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.20 Pain Relevance 0.13

Glucosamine inhibited c-jun amino-terminal kinase and p38 phosphorylation, and consequently c-jun binding activity.

Phosphorylation (phosphorylation) of c-jun

9) Confidence 0.29 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212570 Disease Relevance 0 Pain Relevance 0

Glucosamine inhibited c-jun amino-terminal kinase and p38 phosphorylation, and consequently c-jun binding activity.

Phosphorylation (phosphorylation) of c-jun

10) Confidence 0.29 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212570 Disease Relevance 0 Pain Relevance 0

stimulated phosphorylation of c-jun amino-terminal kinase, p38 MAPK and extracellular signal-regulated kinase-1/2.

Phosphorylation (phosphorylation) of c-jun

11) Confidence 0.29 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212570 Disease Relevance 0 Pain Relevance 0

Acetaldehyde can also induce apoptosis via activation of stress signaling such as c-Jun phosphorylation [34,106,107].

Phosphorylation (phosphorylation) of c-Jun associated with stress and apoptosis

12) Confidence 0.24 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 0.78 Pain Relevance 0.24

and other transcription factors like AP-1 and NF-?

Phosphorylation (factors) of AP-1

13) Confidence 0.23 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.26 Pain Relevance 0.12

Upon activation, JNKs translocate to the nucleus to phosphorylate and enhance the transcriptional activity of JUN [7].

Phosphorylation (phosphorylate) of JUN in nucleus

14) Confidence 0.20 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.78 Pain Relevance 0.10

ERK phosphorylates and thereby activates downstream targets like the transcription factor c-Jun.

Phosphorylation (phosphorylates) of c-Jun

15) Confidence 0.19 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.04 Pain Relevance 0

Vpr activates the DNA binding activity of AP-1 by promoting the phosphorylation of cFos and cJun in monocytes and macrophages [267].

Phosphorylation (phosphorylation) of cJun in macrophages

16) Confidence 0.15 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.61 Pain Relevance 0

It has been demonstrated that during reperfusion, oxidative stress leads to activation and translocation of JNK to the nucleus, where phosphorylation of transcription factors, such as c-Jun occurs.

Phosphorylation (phosphorylation) of c-Jun in nucleus associated with stress

17) Confidence 0.13 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.41 Pain Relevance 0.16

Phosphorylation of c-Jun is a prerequisite of AP-1 dimerization and activation.

Phosphorylation (Phosphorylation) of c-Jun

18) Confidence 0.13 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.28 Pain Relevance 0.10

Phosphorylation of GST-c-Jun was then determined by autoradiography.

Phosphorylation (Phosphorylation) of c-Jun

19) Confidence 0.13 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0

Phosphorylation of c-Jun is a prerequisite of AP-1 dimerization and activation.

Phosphorylation (Phosphorylation) of AP-1

20) Confidence 0.13 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.28 Pain Relevance 0.10

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