INT110189

From wiki-pain
Revision as of 20:56, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.02
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.26
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gnaq) signal transduction (Gnaq) plasma membrane (Gnaq)
GTPase activity (Gnaq) protein complex (Gnaq) signal transducer activity (Gnaq)
Anatomy Link Frequency
nucleus 2
ganglia 1
Gnaq (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 22 99.68 Very High Very High Very High
agonist 26 86.68 High High
antidepressant 2 78.80 Quite High
depression 3 59.44 Quite High
Hippocampus 4 48.44 Quite Low
Antinociceptive 8 13.92 Low Low
Spinal cord 8 11.44 Low Low
Intracerebroventricular 2 6.36 Low Low
antagonist 38 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 8 75.00 Quite High
Depression 3 59.44 Quite High
Stress 12 52.12 Quite High
Anxiety Disorder 8 40.12 Quite Low
Targeted Disruption 10 23.52 Low Low
Autism 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These reports demonstrated that: (i) both peptides of the HNS, vasopressin and oxytocin, are present in the PNS and specifically in DRG neurones, (ii) the neurohypophysial hormones are involved in the regulation of the inositol phosphate pathway through Gq protein coupled receptors, suggesting the existence of vasopressin receptors in ganglia cells and the possibility for the peptides to induce the production of inositol trisphosphate (InsP3) responsible for the activation of Ca2+ release channels localized on the membrane of the endoplasmic reticulum.
Regulation (regulation) of Gq in ganglia
1) Confidence 0.02 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.11 Pain Relevance 0.03
Regulators of G protein signaling 4 and Galphaq protein levels in the hypothalamic paraventricular nucleus were not altered during fluoxetine treatment.
Regulation (Regulators) of Galphaq protein in nucleus associated with fluoxetine
2) Confidence 0.00 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721328 Disease Relevance 0.07 Pain Relevance 0.79
Regulators of G protein signaling 4 and Galphaq protein levels in the hypothalamic paraventricular nucleus were not altered during fluoxetine treatment.
Neg (not) Regulation (altered) of Galphaq protein in nucleus associated with fluoxetine
3) Confidence 0.00 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721328 Disease Relevance 0.07 Pain Relevance 0.81

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox