INT110211

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.16
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CSRP1)
Anatomy Link Frequency
liver 2
leukocytes 2
CSRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 2 99.32 Very High Very High Very High
spinal inflammation 3 97.84 Very High Very High Very High
Restless leg syndrome 60 95.84 Very High Very High Very High
Inflammatory response 6 94.80 High High
Arthritis 1 83.32 Quite High
aspirin 11 80.72 Quite High
Osteoarthritis 1 74.56 Quite High
Inflammatory marker 4 58.32 Quite High
Inflammation 9 50.00 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 2 99.32 Very High Very High Very High
Seronegative Spondarthritis 4 97.84 Very High Very High Very High
Increased Venous Pressure Under Development 62 95.84 Very High Very High Very High
Leukocytosis 1 95.20 Very High Very High Very High
INFLAMMATION 19 94.80 High High
Fever 1 92.44 High High
Lung Cancer 2 88.88 High High
Arthritis 1 83.32 Quite High
Disease 2 80.64 Quite High
Cv Unclassified Under Development 4 74.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After the second cycle, the levels of leukocytes and CRP were remarkably decreased, and the severe back pain was also alleviated.
Negative_regulation (decreased) of Gene_expression (levels) of CRP in leukocytes associated with backache
1) Confidence 0.43 Published 2003 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 12722684 Disease Relevance 0.54 Pain Relevance 0.19
These patients were not on statin therapy which has been shown to reduce IL-6 and CRP production in the endothelial and liver cells [26,27].
Negative_regulation (reduce) of Gene_expression (production) of CRP in liver
2) Confidence 0.32 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 1.08 Pain Relevance 0.77
No statistical correlation was found between p40 IL12/40 serum levels and each of BASDAI, ESR, CRP, serum levels of IL 17, MMP 3.
Negative_regulation (levels) of Gene_expression (levels) of CRP
3) Confidence 0.28 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.53 Pain Relevance 0.29

General Comments

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