INT110332

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.48
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
choroid plexus 1
adipose tissues 1
adipocyte 1
Slc12a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 14 91.56 High High
Action potential 3 79.68 Quite High
Central nervous system 8 62.32 Quite High
ischemia 2 59.12 Quite High
tolerance 6 9.76 Low Low
fibrosis 8 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
TRP channel 6 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 8 98.32 Very High Very High Very High
Obesity 100 97.28 Very High Very High Very High
Injury 8 90.24 High High
Hypoxia 8 83.04 Quite High
Diabetes Mellitus 8 72.00 Quite High
Body Weight 12 69.76 Quite High
Cv Unclassified Under Development 2 59.12 Quite High
Hyperlipidemia 4 48.00 Quite Low
Disorder Of Lipid Metabolism 12 46.32 Quite Low
Impaired Glucose Tolerance 6 9.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KCC3 and weaker KCC3a was detected in myelin of larger axons.
Gene_expression (detected) of KCC3
1) Confidence 0.69 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12736353 Disease Relevance 0.64 Pain Relevance 0.60
KCC3 and weaker KCC3a was detected in myelin of larger axons.
Gene_expression (detected) of KCC3a
2) Confidence 0.60 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12736353 Disease Relevance 0.64 Pain Relevance 0.59
A possible explanation is that in the mammalian choroid plexus K+ efflux at the basolateral membrane is mediated via the K+-Cl- cotransporter (KCC3) which is expressed at this membrane in rat choroid plexus [76].
Gene_expression (expressed) of KCC3 in choroid plexus
3) Confidence 0.08 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0.03
Therefore, KCL may contribute to the decreased adipocyte size seen by inhibiting aP2 and PPAR?
Spec (may) Gene_expression (may) of KCL in adipocyte
4) Confidence 0.08 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC3002919 Disease Relevance 0.66 Pain Relevance 0
Although there were no significant differences in the average size in mesenteric adipose tissues between the KCL and control groups, the average size in the acetic acid group was greater than that in the KCL group (P = 0.069).
Gene_expression (group) of KCL in adipose tissues
5) Confidence 0.07 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC3002919 Disease Relevance 0.54 Pain Relevance 0

General Comments

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