INT110384

Context Info Confidence 0.08 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.31 Pain Relevance 0.20

protein complex (Prkaca, Akap11) cytoplasm (Prkaca, Akap11) plasma membrane (Prkaca, Akap11) nucleoplasm (Prkaca) mitochondrion (Prkaca) Golgi apparatus (Prkaca)

Prkaca (Rattus norvegicus) Akap11 (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 1 100.00 Pain 1 76.04 Hyperalgesia 1 72.44

Disease Link Frequency Relevance Heat Nociception 2 92.96 Pain 1 76.04 Hyperalgesia 1 72.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The sensitization was, however, inhibited when the specific PKA antagonist PKI(14-22) was added to the pipette solution or when PKA coupling to A kinase anchoring protein (AKAP) was disrupted with InCELLect StHt-31 uncoupling peptide.

PKA Binding (disrupted) of AKAP associated with antagonist

1) Confidence 0.08 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 12740405 Disease Relevance 0.31 Pain Relevance 0.20

General Comments

This test has worked.