INT110539

From wiki-pain
Revision as of 00:00, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.75
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNK18)
Anatomy Link Frequency
pore 1
KCNK18 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 3 99.98 Very High Very High Very High
lidocaine 2 96.96 Very High Very High Very High
trigeminal ganglion 1 96.56 Very High Very High Very High
isoflurane 9 96.12 Very High Very High Very High
Migraine 7 94.72 High High
Spinal cord 16 93.56 High High
Potency 2 92.60 High High
halothane 3 90.64 High High
potassium channel 9 87.32 High High
Pain 1 80.80 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 96.56 Very High Very High Very High
Headache 3 94.72 High High
Migraine With Aura 4 91.56 High High
Pain 1 80.80 Quite High
Headache Disorders 1 71.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amide local anesthetics inhibited the rodent TRESKs at almost 10-fold smaller concentrations than that which inhibit human TRESK.
Negative_regulation (inhibit) of TRESK associated with local anesthetic
1) Confidence 0.51 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 16192517 Disease Relevance 0 Pain Relevance 0.49
Functional characterization of this mutation demonstrates that it causes a complete loss of TRESK function and that the mutant subunit suppresses wild-type channel function through a dominant-negative effect, thus explaining the dominant penetrance of this allele.
Negative_regulation (loss) of TRESK
2) Confidence 0.43 Published 2010 Journal Nat. Med. Section Abstract Doc Link 20871611 Disease Relevance 0.75 Pain Relevance 0.94
Unlike human TRESK, the rodent TRESKs are strongly inhibited by acidic extracellular pH in the physiologic range.
Negative_regulation (inhibited) of TRESK
3) Confidence 0.38 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 16192517 Disease Relevance 0 Pain Relevance 0.45
Amide and ester local anesthetics inhibit TRESK in a concentration-dependent manner but at concentrations generally larger than those that inhibit other tandem pore domain K channels.
Negative_regulation (inhibit) of TRESK in pore associated with local anesthetic
4) Confidence 0.38 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15562060 Disease Relevance 0 Pain Relevance 0.42
Functional analysis demonstrated TRESK to be inhibited by unsaturated free fatty acids such as arachidonic acid and docosahexaenoic acid.
Negative_regulation (inhibited) of TRESK
5) Confidence 0.36 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12754259 Disease Relevance 0 Pain Relevance 0.25
Pharmacological analysis showed TRESK to be inhibited by previously reported K+ channel inhibitors Ba2+, propafenone, glyburide, lidocaine, quinine, quinidine, and triethanolamine.
Negative_regulation (inhibited) of TRESK associated with lidocaine
6) Confidence 0.36 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12754259 Disease Relevance 0 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox