INT110764

Context Info Confidence 0.09 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.08 Pain Relevance 0.05

Tbt1 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 3 91.04 Pain 2 25.00 Eae 5 5.00 Hippocampus 4 5.00 cytokine 2 5.00 anesthesia 1 5.00 isoflurane 1 5.00 Neurotransmitter 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 95 97.68 Disease 27 86.40 Apoptosis 24 81.32 Muscle Disease 10 50.00 Death 1 45.36 Muscle Weakness 17 5.00 Convulsion 13 5.00 Bone Disease 12 5.00 Frontotemporal Dementia 8 5.00 Cognitive Disorder 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The fact that the use of TBT in antifouling paints was banned in 1991 for small boats within the European Community seems not to have resulted in a decrease of TBT levels in marine biota.

Negative_regulation (decrease) of TBT

1) Confidence 0.09 Published 2003 Journal Environ. Sci. Technol. Section Abstract Doc Link 12775042 Disease Relevance 0 Pain Relevance 0

The Bone Surface area/Bone Volume (BS/BV), Trabecular Space (Tb.Sp) was not different, but significantly decreased Trabecular Pattern Factor (Tb.P.F) and increased Cortical wall Thickness (C.Th) in knock-in mice was observed compared to WT mice (Table 2).

Negative_regulation (decreased) of Trabecular Pattern Factor associated with targeted disruption

2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 1.08 Pain Relevance 0.05

General Comments

This test has worked.