INT110957

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Context Info
Confidence 0.35
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.30
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)
intracellular (Bcl2) cytoplasm (Bcl2) cell proliferation (Bcl2)
Anatomy Link Frequency
endothelial cell 2
cerebellum 2
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 1 96.76 Very High Very High Very High
metalloproteinase 32 65.28 Quite High
Inflammation 34 50.00 Quite Low
chemokine 4 48.96 Quite Low
cytokine 11 48.36 Quite Low
ischemia 1 43.48 Quite Low
COX-2 inhibitor 8 25.00 Low Low
cINOD 3 25.00 Low Low
COX2 1 25.00 Low Low
addiction 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 94 100.00 Very High Very High Very High
Cancer 12 98.82 Very High Very High Very High
Obesity 126 85.68 High High
Death 8 80.68 Quite High
Necrosis 6 60.96 Quite High
Targeted Disruption 31 53.52 Quite High
INFLAMMATION 38 50.00 Quite Low
Cognitive Disorder 1 49.36 Quite Low
Cv Unclassified Under Development 1 43.48 Quite Low
Hypoxia 1 43.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypothyroid rats display increased caspase 3 activity and increased levels of pro-apoptotic Bcl2 members and decreased Bcl2 family members in the cortex [7] cerebellum [8], and hippocampus [9].
Positive_regulation (increased) of Positive_regulation (increased) of Bcl2 in cerebellum associated with hippocampus and apoptosis
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 1.23 Pain Relevance 0.05
COX-2 appears to: (a) play a key role in the release and activity of proangiogenic proteins; (b) result in the production of eicosanoid products TXA2, PGI2, PGE2 that directly stimulate endothelial cell migration and angiogenesis in vivo, and (c) result in enhanced tumor cell, and possibly, vascular endothelial cell survival by upregulation of the antiapoptotic proteins Bcl-2 and/or activation of PI3K-Akt.
Positive_regulation (upregulation) of Positive_regulation (upregulation) of Bcl-2 in endothelial cell associated with cancer
2) Confidence 0.24 Published 2003 Journal Prog Exp Tumor Res Section Abstract Doc Link 12795055 Disease Relevance 0.34 Pain Relevance 0
Furthermore, quantitative realtime PCR analysis suggested that the protective effect of insulin is mediated through stimulation of Bcl-2 mRNA rather than suppression of Bax mRNA expression (Figure S2C, S2D).
Positive_regulation (mediated) of Positive_regulation (stimulation) of Bcl-2 mRNA
3) Confidence 0.06 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.73 Pain Relevance 0.09

General Comments

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