INT111145

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.21
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
macrophage 2
Spleen 2
Ifng (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 9 99.82 Very High Very High Very High
withdrawal 5 99.80 Very High Very High Very High
substance P 6 98.34 Very High Very High Very High
Paracetamol 6 96.52 Very High Very High Very High
Neuropeptide 6 92.92 High High
Morphine 3 89.44 High High
Inflammation 6 88.80 High High
guanethidine 1 88.40 High High
antagonist 4 87.72 High High
agonist 2 86.76 High High
Disease Link Frequency Relevance Heat
Salmonella Infection 1 99.86 Very High Very High Very High
Hepatotoxicity 5 97.24 Very High Very High Very High
Bacterial Infection 2 95.04 Very High Very High Very High
INFLAMMATION 6 88.80 High High
Gastritis 6 75.00 Quite High
Stress 2 75.00 Quite High
Stomach Cancer 4 71.76 Quite High
Disease 2 67.16 Quite High
Ulcers 2 66.84 Quite High
Pain 1 62.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dynorphin-A(1-17) decreases nitric oxide release and cytotoxicity induced with lipopolysaccharide plus interferon-gamma in murine macrophage cell line J774.
Negative_regulation (decreases) of Positive_regulation (induced) of interferon-gamma in macrophage associated with dynorphin
1) Confidence 0.41 Published 2003 Journal Biomed. Pharmacother. Section Title Doc Link 14568229 Disease Relevance 0 Pain Relevance 0.55
Spleen cells from mice undergoing withdrawal also had decreased splenic mRNA and/or protein levels of IL-1beta, IL-1Ra, TNF-alpha, IL-12, and IFN-gamma.
Negative_regulation (decreased) of Positive_regulation (levels) of IFN-gamma in Spleen associated with withdrawal
2) Confidence 0.39 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 14597094 Disease Relevance 0 Pain Relevance 0.50
To conclude suppression of IFN-gamma and increase in alpha-class GSTs expression may exert a protective role in acute hepatotoxicity of APAP and 5 kGy GIHA showed comparable protective effect to that of UIHA.
Negative_regulation (suppression) of Positive_regulation (increase) of IFN-gamma associated with paracetamol and hepatotoxicity
3) Confidence 0.39 Published 2008 Journal Chem. Biol. Interact. Section Abstract Doc Link 18237725 Disease Relevance 0.31 Pain Relevance 0.29
The OVA challenge-induced IFN-gamma and ET-1 productions were inhibited in IL-18(-/-) immunized mice, as well as ET-1 production in IFN-gamma(-/-) immunized mice.
Negative_regulation (inhibited) of Positive_regulation (challenge-induced) of IFN-gamma
4) Confidence 0.30 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17194566 Disease Relevance 0.28 Pain Relevance 0.39
Splenocytes were obtained and cultured in vitro with H. pylori sonicate to evaluate induction of interferon gamma (IFN-gamma) and interleukin 4 (IL-4) secretion.
Negative_regulation (evaluate) of Positive_regulation (induction) of IFN-gamma
5) Confidence 0.21 Published 2003 Journal Int. Immunopharmacol. Section Abstract Doc Link 12810355 Disease Relevance 0.64 Pain Relevance 0.15
Splenocytes were obtained and cultured in vitro with H. pylori sonicate to evaluate induction of interferon gamma (IFN-gamma) and interleukin 4 (IL-4) secretion.
Negative_regulation (evaluate) of Positive_regulation (induction) of interferon gamma
6) Confidence 0.21 Published 2003 Journal Int. Immunopharmacol. Section Abstract Doc Link 12810355 Disease Relevance 0.64 Pain Relevance 0.15
This is shown by blocking SP action in which mice show increased susceptibility to Salmonella infections since induction of IFN-gamma is significantly reduced.
Negative_regulation (reduced) of Positive_regulation (induction) of IFN-gamma associated with salmonella infection and substance p
7) Confidence 0.15 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 15353350 Disease Relevance 0.33 Pain Relevance 0.58

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