INT111161

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Context Info
Confidence 0.40
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.62
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (EFNA1) plasma membrane (EFNA1) cell-cell signaling (EFNA1)
Anatomy Link Frequency
finger 1
bile 1
EFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 26 100.00 Very High Very High Very High
Bile 2 100.00 Very High Very High Very High
cytokine 14 84.08 Quite High
metalloproteinase 11 60.56 Quite High
pain pelvic 2 40.80 Quite Low
Inflammation 31 36.68 Quite Low
chemokine 10 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 26 100.00 Very High Very High Very High
Cancer 62 99.16 Very High Very High Very High
Disease 50 98.92 Very High Very High Very High
Skin Cancer 9 98.32 Very High Very High Very High
Cervical Cancer 69 96.52 Very High Very High Very High
Pulmonary Disease 99 89.72 High High
Adhesions 11 88.56 High High
Vulvar Cancer 12 86.76 High High
Apoptosis 20 83.20 Quite High
Reprotox - General 3 10 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may play an important role in the development of a subset of early cervical cancers.
Positive_regulation (increased) of EphrinA-1 associated with cervical cancer and skin cancer
1) Confidence 0.40 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.93 Pain Relevance 0
The increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may be important factors in the development of a subset of early cervical cancers.
Positive_regulation (increased) of EphrinA-1 associated with cervical cancer and skin cancer
2) Confidence 0.40 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.89 Pain Relevance 0
The increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may play an important role in the development of a subset of early cervical cancers.
Positive_regulation (increased) of EphrinA-1 associated with cervical cancer and skin cancer
3) Confidence 0.27 Published 2008 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC2424178 Disease Relevance 0.69 Pain Relevance 0
Egr-1 is a zinc finger transcription factor classified as an immediate-early response protein, which is potentially induced by a variety of cellular stressors (Lee et al 1996).
Positive_regulation (induced) of immediate-early response protein in finger
4) Confidence 0.08 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629979 Disease Relevance 0.49 Pain Relevance 0.13
Group 1 target genes are up-regulated during the normal window of implantation but significantly decreased in women with endometriosis: IL-15, proline-rich protein, B61, Dickkopf-1, glycodelin, N-acetylglucosamine-6-O-sulfotransferase, G0S2 protein, and purine nucleoside phosphorylase.
Positive_regulation (up-regulated) of B61 associated with endometriosis
5) Confidence 0.05 Published 2003 Journal Endocrinology Section Abstract Doc Link 12810542 Disease Relevance 0.79 Pain Relevance 0.28
Selected dysregulated genes were randomly chosen and validated with RT-PCR and/or Northern/dot-blot analyses, and confirmed up-regulation of collagen alpha2 type I, 2.6-fold; bile salt export pump, 2.0-fold; and down-regulation of N-acetylglucosamine-6-O-sulfotransferase (important in synthesis of L-selectin ligands), 1.7-fold; glycodelin, 51.5-fold; integrin alpha2, 1.8-fold; and B61 (Ephrin A1), 4.5-fold.
Positive_regulation (confirmed) of B61 in bile associated with bile
6) Confidence 0.04 Published 2003 Journal Endocrinology Section Abstract Doc Link 12810542 Disease Relevance 0.82 Pain Relevance 0.28

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