INT111208

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.17
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (UGT2B7) lipid metabolic process (UGT2B7)
Anatomy Link Frequency
2B7 2
macula densa 1
kidney 1
UGT2B7 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 3 100.00 Very High Very High Very High
Patient controlled alalgesia 1 98.84 Very High Very High Very High
Morphine 15 98.76 Very High Very High Very High
Cancer pain 1 96.60 Very High Very High Very High
Opioid 1 96.44 Very High Very High Very High
Analgesic 1 94.80 High High
medulla 6 90.00 High High
cINOD 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer Pain 1 96.60 Very High Very High Very High
Cancer 1 75.00 Quite High
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the variation in the uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7) gene in patients receiving patient-controlled analgesia with morphine.
Spec (investigated) Positive_regulation (variation) of UGT2B7 in 2B7 associated with patient controlled alalgesia and morphine
1) Confidence 0.49 Published 2003 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 12811366 Disease Relevance 0 Pain Relevance 0.62
This study evaluated genetic variation in the mu-opioid receptor, betaarrestin2, stat6 and uridine diphosphate-glucuronysltransferase 2B7 (UGT2B7) genes, in patients who responded to morphine vs those who were switched to alternative opioids.
Positive_regulation (variation) of UGT2B7 in 2B7 associated with opioid receptor, opioid and morphine
2) Confidence 0.49 Published 2005 Journal Pharmacogenomics J. Section Abstract Doc Link 16103897 Disease Relevance 0.17 Pain Relevance 0.73
Additionally, UGT1A and UGT2B7 expression was demonstrated in the macula densa, supporting a potential role of UGTs in regulating aldosterone.
Positive_regulation (demonstrated) of UGT2B7 in macula densa
3) Confidence 0.22 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17698974 Disease Relevance 0 Pain Relevance 0.07
Using human kidney sections and human kidney cortical microsomes (HKCM) and human kidney medullary microsomes (HKMM), we combined immunohistochemistry to investigate UGT1A and UGT2B7 expression with in vitro microsomal studies to determine the kinetics of S-naproxen acyl glucuronidation.
Spec (investigate) Positive_regulation (investigate) of UGT2B7 in kidney
4) Confidence 0.22 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17698974 Disease Relevance 0 Pain Relevance 0.04

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