INT111431

From wiki-pain
Revision as of 21:37, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.34
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn8a) plasma membrane (Scn8a) transmembrane transport (Scn8a)
Anatomy Link Frequency
myocytes 2
neurons 2
Scn8a (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 3 100.00 Very High Very High Very High
Action potential 4 93.16 High High
tetrodotoxin 5 80.60 Quite High
Nav1.6 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Death 1 92.32 High High
Ataxia 1 85.92 High High
Tremor 1 85.28 High High
Targeted Disruption 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test the effect of cerebellar Na(V)1.6 on motor coordination in mice, we used the Cre-lox system to eliminate Scn8a expression exclusively in Purkinje neurons (Purkinje KO) and/or granule neurons (granule KO).
Negative_regulation (eliminate) of Gene_expression (expression) of Scn8a in neurons
1) Confidence 0.43 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16687615 Disease Relevance 0.34 Pain Relevance 0.10
Mutant med mice are ataxic and lack expression of the Scn8a gene, which encodes the NaV1.6 protein.
Negative_regulation (lack) of Gene_expression (expression) of Scn8a
2) Confidence 0.42 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12832512 Disease Relevance 0 Pain Relevance 0.28
In this study, we characterized transient (I(NaT)), persistent (I(N)(aP)), and resurgent (I(res)) sodium currents in Na(v)1.6-null mice (med mouse, Na(v)1.6(-/-)) lacking expression of the sodium channel gene Scn8a.
Negative_regulation (lacking) of Neg (lacking) Gene_expression (expression) of Scn8a associated with sodium channel
3) Confidence 0.42 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17522178 Disease Relevance 0 Pain Relevance 0.12
Patch-clamp experiments were performed to investigate the behavior of voltage-activated inward currents in vas deferens myocytes from Na(V)1.6-null mice (Na(V)1.6(-/-)) lacking the expression of the Na(+) channel gene, Scn8a, and their wild-type littermates (Na(V)1.6(+/+)).
Negative_regulation (lacking) of Neg (lacking) Gene_expression (expression) of Scn8a in myocytes
4) Confidence 0.40 Published 2010 Journal J. Cell. Physiol. Section Abstract Doc Link 20054822 Disease Relevance 0 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox